The Rise of Synaptic Density PET Imaging

[en] Many neurological disorders are related to synaptic loss or pathologies. Before the boomof positrons emission tomography (PET) imaging of synapses, synaptic quantification could onlybe achievedin vitroon brain samples after autopsy or surgical resections. Until the mid-2010s,electron microscopy and immunohistochemical labelling of synaptic proteins were the gold-standardmethods for such analyses. Over the last decade, several PET radiotracers for the synaptic vesicle 2Aprotein have been developed to achievein vivosynapses visualization and quantification. Differentstrategies were used, namely radiolabelling with either11C or18F, preclinical development in rodentand non-human primates, and binding quantification with different kinetic modelling methods. Thisreview provides an overview of these PET tracers and underlines their perspectives and limitationsby focusing on radiochemical aspects, as well as preclinical proof-of-concept and the main clinicaloutcomes described so far.

Disciplines :

Neurology

Author, co-author :

Becker, Guillaume ; Université de Liège - ULiège > Département de Psychologie > Département de Psychologie

Dammicco, Sylvestre ; Université de Liège - ULiège > GIGA CRC In vivo Imaging - Radiochemistry

Bahri, Mohamed Ali ; Université de Liège - ULiège > GIGA CRC In vivo Imaging - Aging & Memory

SALMON, Eric ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Centre de jour interdisciplinaire des troubles de la mémoire

Language :

English

Title :

The Rise of Synaptic Density PET Imaging

Publication date :

14 May 2020

Journal title :

Molecules

eISSN :

1420-3049

Publisher :

Multidisciplinary Digital Publishing Institute (MDPI), Switzerland

Volume :

25, 2303

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 05 February 2021

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