[en] Crystal X-ray quality is usually evaluated by looking at data quality parameters such as (relative) Wilson B-factor,
resolution, R-factors, signal-to-noise ratio, and others. As these parameters are correlated, most studies focus on one or two of them.
As part of a study of the effects of microgravity on X-ray quality, full data sets of 35 ferritin crystals (17 PromISS-4 “space”
crystals and 18 from the ground control) were collected. Sixty-three parameters commonly used as indicative of X-ray data quality
taken from the output of the processing, scaling, and merging software packages were analyzed. This highly dimensional “quality
parameter dataset” was reduced using a principal component analysis. About 78% of the variability in the data set could be explained
with the first four principal components. A score-plot in this four-dimensional space clearly showed two tendencies, one for the
crystals grown in space and one for the ground crystals. The differences between the two groups are observed irrespective of the
software package. They can be attributed to the first principal component and reflect the superior quality of the space crystals.
Research Center/Unit :
Giga-Systems Biology and Chemical Biology - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Maes, Dominique; Vrije Universiteit Brussel - VUB
Evrard, Christine ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Gavira, Jose; Laboratorio de Estudios Cristalograficos IACT
Sleutel, Mike; Vrije Universiteit Brussel - VUB
Van de Weerdt, Cécile ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Otalora, Fermin; Laboratorio de Estudios Cristalograficos, IACT
Garcia-Ruiz, Juan Ma; Laboratorio de Estudios Cristalograficos, IACT
Nicolis, Grégoire; Université Libre de Bruxelles - ULB
Martial, Joseph ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Bibliography
Helliwell, J.R., (1988) J. Cryst. Growth, 90, pp. 259-272
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