Age Determination by Skeleton; Body Height; Humans; Growth Disorders; Growth Hormone; Insulin; Weight Gain; Osteocalcin
Abstract :
[en] The effect of GH administration was evaluated over 2 yr in 50 short, prepubertal, non-GH deficient children born small for gestational age, who had been randomly allocated to a group receiving no treatment or daily sc GH treatment at a dose of 0.2 or 0.3 IU/kg. At the start of the study, mean age was 5.2 yr, bone age was 4.0 yr, height SDS was -3.5, height velocity SDS was -0.8, weight SDS was -2.7, and body mass index SDS was -1.9. Catch-up growth was observed in none of the untreated and all of the treated children. The response to GH treatment included a near doubling of growth velocity and of weight gain and a mean height increment of more than 2 SDS. GH treatment was associated with a distinct acceleration of bone maturation. The differences between the growth responses evoked by the two GH doses were minor. The prepubertal GH-induced catch-up growth was associated with elevated serum concentrations of insulin, insulin-like growth factor-I, insulin-like growth factor binding protein-3, and osteocalcin, whereas insulin-like growth factor-II levels remained unaltered. GH treatment was well tolerated. In conclusion, high-dose GH administration over 2 yr is emerging as a potential therapy to increase the short stature that results from insufficient catch- up growth in young children born small for gestational age. The long-term impact of this approach remains to be delineated.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
De Zegher, F.; Belg. Stud. Grp. Pediat. Endocrinol., Department of Pediatrics, University of Leuven, Belgium, Department of Pediatrics, University Hospital Gasthuisberg, 3000 Leuven, Belgium
Maes, M.
Gargosky, S. E.; Department of Pediatrics, Oregon Health Sciences University, Portland, OR 97201, United States
Heinrichs, C.
Du Caju, M. V.
Thiry, G.
De Schepper, J.
Craen, M.
Breysem, L.; Department of Radiology, University of Leuven, Belgium
Löfström, A.; Pharmacia Peptide Hormones, Stockholm, Sweden
Jönsson, P.; Pharmacia Peptide Hormones, Stockholm, Sweden
Bourguignon, Jean-Pierre ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Malvaux, P.
Rosenfeld, R. G.; Department of Pediatrics, Oregon Health Sciences University, Portland, OR 97201, United States
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