Article (Scientific journals)
Chimeric Antigen Receptor-T-Cell Therapy for B-Cell Hematological Malignancies : An Update of the Pivotal Clinical Trial Center
Roex, Gils; Feys, Tom; BEGUIN, Yves et al.
2020In Pharmaceutics, 12, p. 194
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Keywords :
CART-T cells; immunotherapy; B-cell malignancies; CD19; BCMA
Abstract :
[en] Chimeric antigen receptor (CAR)-T-cell therapy is an innovative form of adoptive cell therapy that has revolutionized the treatment of certain hematological malignancies, including B-cell non-Hodgkin lymphoma (NHL) and B-cell acute lymphoblastic leukemia (ALL). The treatment is currently also being studied in other B-cell neoplasms, including multiple myeloma (MM) and chronic lymphocytic leukemia (CLL). CD19 and B-cell maturation antigen (BCMA) have been the most popular target antigens for CAR-T-cell immunotherapy of these malignancies. This review will discuss the efficacy and toxicity data from the pivotal clinical studies of CD19- and BCMA-targeted CAR-T-cell therapies in relapsed/refractory B-cell malignancies (NHL, ALL, CLL) and MM, respectively.
Disciplines :
Hematology
Author, co-author :
Roex, Gils
Feys, Tom
BEGUIN, Yves  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service d'hématologie clinique
Kerre, Tessa
Poiré, Xavier
Lewalle, Philippe
Vandenberghe, Peter
Bron, Dominique
Anguille, Sebastien
Language :
English
Title :
Chimeric Antigen Receptor-T-Cell Therapy for B-Cell Hematological Malignancies : An Update of the Pivotal Clinical Trial Center
Publication date :
2020
Journal title :
Pharmaceutics
ISSN :
1999-4923
Publisher :
MDPI AG
Volume :
12
Pages :
194
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 29 January 2021

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