[en] The relationship between the two biotypes of bovine viral diarrhoea virus (BVDV) and the biological responses they induce was studied in 3- to 6-month-old calves inoculated intranasally with a homologous pair of non-cytopathic and cytopathic strains. Marked differences in virological and serological events occurred following exposure to a specific BVDV strain. The non-cytopathic biotype was frequently recovered from nasal secretions and blood cells during the first 28 days post-inoculation whereas the cytopathic counterpart was detected infrequently in nasopharyngeal swabs only. There was no correlation of the recovery of infectious virus in vivo with the biotype-specific neutralizing humoral immune response. Furthermore, seroconversion did not correlate with resistance to reinfection as judged by the transient viraemia and/or shedding of virus observed in a challenge experiment.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Lambot, M.; Université de Liège - ULiège > Faculty of Veterinary Medicine > Immunology/Vaccinology
Joris, E.; Université de Liège - ULiège > Faculty of Veterinary Medicine > Immunology/Vaccinology
Douart, A.; Université de Liège - ULiège > Faculty of Veterinary Medicine > Immunology/Vaccinology
Lyaku, J.; Université de Liège - ULiège > Faculty of Veterinary Medicine > Immunology/Vaccinology
Letesson, J. J.; Université de Liège - ULiège > Faculty of Veterinary Medicine > Immunology/Vaccinology
Pastoret, Paul-Pierre ; Université de Liège - ULiège > Faculty of Veterinary Medicine > Immunology/Vaccinology
Language :
English
Title :
Evidence for Biotype-Specific Effects of Bovine Viral Diarrhoea Virus on Biological Responses in Acutely Infected Calves
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