Reference : Mechanical Forces Orchestrate Brain Development.
Scientific journals : Article
Human health sciences : Neurology
Mechanical Forces Orchestrate Brain Development.
Javier Torrent, Míriam [Université de Liège - ULiège > > Stem Cells-Molecular Regulation of Neurogenesis >]
Zimmer-Bensch, Geraldine [> >]
Nguyen, Laurent mailto [Université de Liège - ULiège > > Stem Cells-Molecular Regulation of Neurogenesis >]
Trends in neurosciences
Yes (verified by ORBi)
[en] cell migration ; cerebral cortex ; cytoskeleton ; extracellular matrix ; mechanotransduction
[en] During brain development, progenitors generate successive waves of neurons that populate distinct cerebral regions, where they settle and differentiate within layers or nuclei. While migrating and differentiating, neurons are subjected to mechanical forces arising from the extracellular matrix, and their interaction with neighboring cells. Changes in brain biomechanical properties, during its formation or aging, are converted in neural cells by mechanotransduction into intracellular signals that control key neurobiological processes. Here, we summarize recent findings that support the contribution of mechanobiology to neurodevelopment, with focus on the cerebral cortex. Also discussed are the existing toolbox and emerging technologies made available to assess and manipulate the physical properties of neurons and their environment.
Researchers ; Professionals ; Students
Copyright © 2020 Elsevier Ltd. All rights reserved.

File(s) associated to this reference

Fulltext file(s):

Restricted access
TINS (2021) Javier-Torrent_in press.pdfPublisher postprint1.48 MBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.