Article (Scientific journals)
Characteristics and treatment regimens across ERS SHARP severe asthma registries
van Bragt, J. J. M. H.; Adcock, I. M.; Bel, E. H. D. et al.
2020In European Respiratory Journal, 55 (1)
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Keywords :
Article; Belgium; Denmark; European; Hungary; Italy; Netherlands; Poland; Slovenia; Spain; Sweden; United Kingdom
Abstract :
[en] Little is known about the characteristics and treatments of patients with severe asthma across Europe, but both are likely to vary. This is the first study in the European Respiratory Society Severe Heterogeneous Asthma Research collaboration, Patient-centred (SHARP) Clinical Research Collaboration and it is designed to explore these variations. Therefore, we aimed to compare characteristics of patients in European severe asthma registries and treatments before starting biologicals. This was a cross-sectional retrospective analysis of aggregated data from 11 national severe asthma registries that joined SHARP with established patient databases. Analysis of data from 3236 patients showed many differences in characteristics and lifestyle factors. Current smokers ranged from 0% (Poland and Sweden) to 9.5% (Belgium), mean body mass index ranged from 26.2 (Italy) to 30.6 kg·m−2 (the UK) and the largest difference in mean pre-bronchodilator forced expiratory volume in 1 s % predicted was 20.9% (the Netherlands versus Hungary). Before starting biologicals patients were treated differently between countries: mean inhaled corticosteroid dose ranged from 700 to 1335 µg·day−1 between those from Slovenia versus Poland when starting anti-interleukin (IL)-5 antibody and from 772 to 1344 µg·day−1 in those starting anti-IgE (Slovenia versus Spain). Maintenance oral corticosteroid use ranged from 21.0% (Belgium) to 63.0% (Sweden) and from 9.1% (Denmark) to 56.1% (the UK) in patients starting anti-IL-5 and anti-IgE, respectively. The severe asthmatic population in Europe is heterogeneous and differs in both clinical characteristics and treatment, often appearing not to comply with the current European Respiratory Society/American Thoracic Society guidelines definition of severe asthma. Treatment regimens before starting biologicals were different from inclusion criteria in clinical trials and varied between countries. Copyright © ERS 2020
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
van Bragt, J. J. M. H.;  Dept of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
Adcock, I. M.;  Molecular Cell Biology Group, National Heart and Lung Institute, Imperial College London, London, United Kingdom
Bel, E. H. D.;  Dept of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
Braunstahl, G.-J.;  Franciscus Gasthuis and Vlietland, Rotterdam, Netherlands
ten Brinke, A.;  Medical Centre Leeuwarden, Leeuwarden, Netherlands
Busby, J.;  Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom
Canonica, G. W.;  Personalised Medicine Clinic, Asthma and Allergy, Humanitas Clinical and Research Centre, Humanitas University, Rozzano, Italy, SANI-Severe Asthma Network Italy, Milan, Italy
Cao, H.;  Novartis Pharmaceuticals Corp., East Hanover, NJ, United States
Chung, K. F.;  Experimental Studies Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom
Csoma, Z.;  National Koranyi Institute of Pulmonology, Budapest, Hungary
Dahlén, B.;  Division of Respiratory Medicine and Allergy, Dept of Medicine, Karolinska University Hospital, Huddinge, Sweden
Davin, E.;  European Lung Foundation, Sheffield, United Kingdom
Hansen, S.;  Center for Clinical Research and Disease Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark, Respiratory Research Unit, Dept of Respiratory Medicine, Bispebjerg University Hospital, Copenhagen, Denmark
Heffler, E.;  Personalised Medicine Clinic, Asthma and Allergy, Humanitas Clinical and Research Centre, Humanitas University, Rozzano, Italy, SANI-Severe Asthma Network Italy, Milan, Italy
Horvath, I.;  National Koranyi Institute of Pulmonology, Budapest, Hungary
Korn, S.;  Universitätsmedizin Mainz, Mainz, Germany, Schwerpunkt Pneumologie, Universitätsmedizin Mainz, Mainz, Germany
Kots, M.;  Global Clinical Development, Chiesi Farmaceutici, Parma, Italy
Kuna, P.;  Dept of Internal Medicine, Asthma and Allergy, Medical University of Lodz, Lodz, Poland
Kwon, N.;  Respiratory Medical Franchise, GSK, Brentford, United Kingdom, SANI-Severe Asthma Network Italy, Milan, Italy
Louis, Renaud ;  Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie
Plaza, V.;  Respiratory Medicine Dept and Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
Porsbjerg, C.;  Respiratory Research Unit, Dept of Respiratory Medicine, Bispebjerg University Hospital, Copenhagen, Denmark
Ramos-Barbon, D.;  Respiratory Medicine Dept and Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
Richards, L. B.;  Dept of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
Škrgat, S.;  University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia
Sont, J. K.;  Dept of Biomedical Data Sciences, Section Medical Decision Making, Leiden University Medical Center, Leiden, Netherlands
Vijverberg, S. J. H.;  Dept of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
Weersink, E. J. M.;  Dept of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
Yasinska, V.;  Division of Respiratory Medicine and Allergy, Dept of Medicine, Karolinska University Hospital, Huddinge, Sweden
Wagers, S. S.;  BioSciConsulting, Maasmechelen, Belgium
Djukanovic, R.;  NIHR Southampton Respiratory Biomedical Research Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
Maitland-Van der Zee, A. H.;  Dept of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
Abenhardt, B.;  Praxis Dr Abenhardt und Jochen Hinrichs-Pavlik, Heidelberg, Germany
Adler, J.;  European Lung Foundation, Sheffield, United Kingdom
Alfonso, R.;  GSK, Durham, NC, United States
Ali, R.;  Barts Health NHS Trust, London, United Kingdom
Alkameh, S.;  Lungenfachpraxis Backnang, Backnang, Germany
Almonacid Sánchez, C.;  Hospital Ramón y Cajal, Madrid, Spain
Alvares, L.;  Novartis Pharma AG, Basel, Switzerland
Anderson, G.;  University of Melbourne, Melbourne, Australia
Assing, K.;  Aalborg University Hospital, Aalborg, Denmark
Ayre, S.;  European Lung Foundation, Sheffield, United Kingdom
Becker, J.;  Facharztpraxis für Pneumologie, Lübeck, Germany
Bergmann, K.;  Charité Berlin Allergie-Centrum, Berlin, Germany
Bieksiene, K.;  Lithuanian University of Health Science, Kaunas, Lithuania
Bjerring, N.;  Odense University Hospital, Odense, Denmark
Blasi, F.;  Milano Respiratory Unit and Adult Cystic Fibrosis Centre, University of Milan, Milan, Italy
Bloemen, P.;  GSK, Zeist, Netherlands
Blum, H.;  MECS Dortmund GmbH, Dortmund, Germany
Böing, S.;  Pneumoplus, Lungen- und Allergiezentrum, Neuss, Germany
Bonavia, M.;  Respiratory Rehabilitation, ASL3, Genoa, Italy
Bossios, A.;  Division of Respiratory Medicine and Allergy, Dept of Medicine, Karolinska University Hospital, Huddinge, Sweden
Bourdin, A.;  PhyMedExp, INSERM, EFS, Université de Montpellier, CHU Montpellier, Montpellier, France
Brons, A.;  European Lung Foundation, Sheffield, United Kingdom
Brusselle, G.;  University of Ghent, UZ Ghent, Ghent, Belgium
Buis, J.;  Teva Pharmaceuticals, Amsterdam, Netherlands
Caiaffa, M.;  University of Foggia, Foggia, Italy
Calabrese, C.;  University of Campania “L. Vanvitelli”, Caserta, Italy
Camiciottoli, G.;  Careggi University Hospital, Florence, Italy
Caruso, C.;  Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy
Castilla Martínez, M.;  Hospital Los Arcos del Mar Menor, Murcia, Spain
Centanni, S.;  Università degli Studi Milano, Respiratory Unit, ASST Santi Paolo e Carlo, Milan, Italy
Cisneros Serrano, C.;  Hospital de La Princesa, Madrid, Spain
Corsico, A.;  IRCCS Policlinico San Matteo Foundation, University of Pavia, Pavia, Italy
Cosmi, L.;  University of Florence, Florence, Italy
Costantino, M.;  “Carlo Poma” Hospital Mantova, Mantova, Italy
Costello, R.;  Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
Crimi, N.;  University of Catania, Catania, Italy
Dahlen, S.;  Karolinska Institutet, Stockholm, Sweden
D'Amato, M.;  “Federico II” University, AO Dei Colli, Naples, Italy
Davies, D.;  Southampton University Hospital, Southampton, United Kingdom
de Borja García-Cosío Piqueras, F.;  Hospital Son Espases Palma Mallorca, Islas Baleares, Spain
Decarlo, G.;  European Federation of Allergy and Airways Diseases (EFA), Brussels, Belgium
Deimling, A.;  Lungenpraxis Schleswig, Schleswig, Germany
Del Giacco, S.;  University of Cagliari, Cagliari, Italy
Diaz Campos, R.;  Hospital 12 Octubre, Madrid, Spain
Djandji, M.;  Medical Affairs, Sanofi Genzyme, Cambridge, MA, United States
Doberer, D.;  Vienna General Hospital, Vienna, Austria
Dupont, L.
Dyett, K.;  European Lung Foundation, Sheffield, United Kingdom
Edelbaher, N.;  University Clinical Centre Maribor, Maribor, Slovenia
Edelmann, M.;  Lungenpraxis Aalen, Aalen, Germany
Ehmann, R.;  Gemeinschaftspraxis für Ambulante Pneumologie mit Allergiezentrum, Stuttgart, Germany
Ekberg-Jansson, A.;  Dept of Research and Development, Region Halland and University of Gothenburg, Gothenburg, Sweden
Farsi, A.;  SOS of Allergology and Clinical Immunology, Azienda USL Toscana Centro, Prato, Italy
Favero, E.;  Vittorio Veneto Hospital, Treviso, Italy
Feimer, J.;  Pneumologie Odeonsplatz, München, Germany
Fletcher, M.;  Respiratory Medical Franchise, GSK, Brentford, United Kingdom
Foschino, B.;  University of Foggia, Foggia, Italy
Frankemölle, B.;  European Lung Foundation, Sheffield, United Kingdom
Gaga, M.;  Athens Chest Hospital Sotiria, Athens, Greece
Gappa, M.;  Marien-Hospital, Klinik für Kinder- und Jugendmedizin, Wesel, Germany
García de Pedro, J.;  Hospital Gregorio, Marañón, Madrid, Spain
García Rivero, J.;  Hospital Laredo, Laredo, Spain
Gasplmayr, M.;  Kardiologische und Fachinternistische ÜBAG Dr Sandrock und Partner, Altdorf bei Nürnberg, Germany
Gebhardt, R.;  Facharzt für Lungenund Brochialheilkunde, Allergologie und Umweltmedizin, Berlin, Germany
Geldmacher, H.;  Pneumologicum, Hannover, Germany
Geltner, C.;  Kreisklinik Bad Reichenhall, Bad Reichenhall, Germany
Gerstlauer, M.;  Klinikum Augsburg, II Kinderklinik, Augsburg, Germany
Gibson, T.;  European Lung Foundation, Sheffield, United Kingdom
Giuseppe, G.;  AO S. Croce e Carle, Cuneo, Italy
Gogoll, C.;  Evangelische Elisabeth Klinik, Berlin, Germany
Grimm-Sachs, V.;  Praxis Dr Grimm-Sachs, Bruchsal, Germany
Grisle, I.;  Riga Eastern Clinical University Hospital, Riga, Latvia
Grün, B.;  Praxis Dr Grün, Bad Windsheim, Germany
Grünewaldt, A.;  Universitätsklinikum Frankfurt, Frankfurt, Germany
Guarnieri, G.;  University of Padua, Padova, Italy
Gullón Blanco, J.;  Hospital San Agustín, Avilés, Asturias, Spain
Hamelmann, E.;  Klinik für Kinder- und Jugendmedizin Kinderzentrum Bethel, Bielefeld, Germany
Hamerlijnck, D.;  European Lung Foundation, Sheffield, United Kingdom
Hammers-Reinhard, A.;  Praxis Hammers-Reinhard, Homburg-Saar, Germany
Hanon, S.;  Free University Brussel, Academic Ziekenhuis, Jette, Belgium
Harzheim, D.;  Waldburg-Zeil Kliniken - Fachkliniken Wangen, Wangen im Allgäu, Germany
Heaney, L.;  Queens University Belfast, Belfast Health and Social Care Trust, Belfast, United Kingdom
Hellmich, S.;  Pneumologie am Schelztor Esslingen, Esslingen, Germany
Herden, M.;  Lungenfachärztlich-Internistische Schwerpunktpraxis, Freising, Germany
Hering, T.;  Arzt für Pneumologie, Allergologie, Schlafmedizin, Berlin, Germany
Herth, F.;  Thoraxklinik Heidelberg gGmbH, Heidelberg, Germany
Hilberg, O.;  Vejle Hospital, Vejle, Denmark
Howarth, P.;  Respiratory Medical Franchise, GSK, Brentford, United Kingdom
Hubatsch, M.;  Lungenarztpraxis Dr Hubatsch, Heilbronn, Germany
Humbert, M.;  Université Paris-Sud, Le Kremlin-Bicêtre, France
Husemann, K.;  MVZ Klinikum Kempten, Praxis für Pneumologie und Allergologie, Kempten, Germany
Idzko, M.;  Klinik für Pneumologie, Universitätsklinikum Freiburg, Freiburg, Germany
Jackson, D.;  Guy's and St Thomas' NHS Trust, King's College London, London, United Kingdom
Jandl, M.;  Hamburger Institut für Therapieforschung GmbH, Hamburg, Germany
Jaumont, X.;  Novartis Pharma AG, Basel, Switzerland
Joos, G.;  UZ Gent, University of Gent, Belgium
Jöst, M.;  Malteser Lungen- und Allergiezentrum Bonn, Bonn, Germany
Jüch, M.;  Pneumologische Praxis am Ulrichplatz, Magdeburg, Germany
Kabesch, M.;  Krankenhaus Barmherzige Brüder Regensburg, Regensburg, Germany
Kaiser-Labusch, P.;  Klinikum Bremen Mitte, Bremen, Germany
Kardos, P.;  Studienzentrum Maingau, Frankfurt, Germany
Käßner, F.;  MECS Cottbus, Cottbus, Germany
Keeley, T.;  Respiratory Medical Franchise, GSK, Brentford, United Kingdom
Kerr, W.;  Respiratory Medical Franchise, GSK, Brentford, United Kingdom
Kirschner, J.;  CIMS Studienzentrum Bamberg, GmbH, Bamberg, Germany
Klimek, L.;  Zentrum für Rhinologie und Allergologie, Wiesbaden, Germany
Koca, M.;  Lungenpraxis Offenbach, Offenbach, Germany
Koczulla, R.;  Schönklinik Berchtesgadener Land, Schönau am Königsee, Germany
Koerner-Rettberg, C.;  Klinik für Kinderund Jugendmedizin, RUB im St Josef-Hospital, Bochum, Germany
Kopac, P.;  Schwerpunkt Pneumologie, Universitätsmedizin Mainz, Mainz, Germany
Kronsbein, J.;  Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Bochum, Germany
Kupryś Lipinska, I.;  Medical University of Lodz, Poland
Langer, M.;  Lungenpraxis Dr Langer Tübingen, Tübingen, Germany
Langeveld, B.;  Deventer Hospital, Deventer, Netherlands
Lantz, A.;  Division of Respiratory Medicine and Allergy, Dept of Medicine, Karolinska University Hospital, Huddinge, Sweden
Lazarinis, N.;  Division of Respiratory Medicine and Allergy, Dept of Medicine, Karolinska University Hospital, Huddinge, Sweden
Lazic, Z.;  University Clinical Centre Kragujevac, Kragujevac, Serbia
Lehtimäki, L.;  University of Tampere, Tampere, Finland
Leuppi, J.;  University Clinic of Internal Medicine, Basel, Switzerland
Lombardi, C.;  Hospital Institute Fondazione Poliambulanza, Brescia, Italy
Lommatzsch, M.;  Universität Rostock, Abteilung Pneumologie, Rostock, Germany
López-Viña, A.;  Hospital Puerta Hierro, Majadahonda, Madrid, Spain
Luca, R.;  Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy
Lúdvíksdóttir, D.;  Landspitali University Hospital, Reykjavik, Iceland
Lüttecke-Hecht, C.;  Lungenfacharztpraxis Dr C. Lüttecke-Hecht, Mainz, Germany
Macchia, L.;  University of Bari - Aldo Moro, Bari, Italy
Magni, T.;  Global Clinical Development, Chiesi Farmaceutici, Parma, Italy
Martínez Rivera, C.;  Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain
Mastoridis, P.;  Novartis Pharmaceuticals Corp., East Hanover, NJ, United States
Mazza, F.;  Presidio Ospedaliero of Pordenone, Pordenone, Italy
Menzella, F.;  Santa Maria Nuova Hospital, Azienda USL di Reggio Emilia IRCCS, Reggio Emilia, Italy
Menzies-Gow, A.;  Royal Brompton Hospital, Imperial College London, London, United Kingdom
Michils, A.;  Hôpital Erasme, Bruxelles, Belgium
Mihãlþan, F.;  University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
Milanese, M.;  Pulmonology Unit, ASL2 Savonese, Pietra Ligure, Savona, Italy
Milger-Kneidinger, K.;  Klinikum der Universität München, München, Germany
Molinska, J.;  Dept of Internal Medicine, Asthma and Allergy, Medical University of Lodz, Lodz, Poland
Montagna, I.;  Global Clinical Development, Chiesi Farmaceutici, Parma, Italy
Montuschi, P.;  Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy
Mülleneisen, N.;  Asthma und Allergiezentrum, Leverskusen, Germany
Muñoz Esquerre, M.;  Hospital Bellvitge, Barcelona, Spain
Nanzer-Kelly, A.;  Guy's and St Thomas' NHS Trust, King's College London, London, United Kingdom
Nenasheva, N.;  Russian Medical Academy for Postgraduate Education, Moscow, Russian Federation
Neurohr, C.;  Klinik Schillerhöhe, Abteilung für Pneumologie und Beatmungsmedizin, Gerlingen, Germany
Nucera, E.;  Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy
Otker, J.;  European Lung Foundation, Sheffield, United Kingdom
Oud, K.;  Hospital Gelderse Vallei, Ede, Netherlands
Paggiaro, P.;  University of Pisa, Pisa, Italy
Parente, R.;  University of Salerno, Salerno, Italy
Parkinson, J.;  Asthma UK, London, United Kingdom
Passalacqua, G.;  IRCCS Policlinico San Martino, University of Genoa, Genoa, Italy
Patberg, N.;  Isala Hospital, Zwolle, Netherlands
Patella, V.;  “Santa Maria della Speranza” Hospital, Battipaglia, Salerno, Italy
Patino, O.;  Teva Pharmaceuticals, Amsterdam, Netherlands
Paulsson, T.;  Respiratory Medical Franchise, GSK, Brentford, United Kingdom
Peche, R.;  Hôpital Vésale, Charleroi, France
Pelaia, G.;  University Magna Graecia of Catanzaro, Catanzaro, Italy
Peress, E.;  Novartis Pharma AG, Basel, Switzerland
Pérez de Llano, L.;  Hospital Lucus Augusti, Lugo, Spain
Pfeffer, P.;  Barts Health NHS Trust and Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
Pfister, P.;  Novartis Pharma AG, Basel, Switzerland
Pilette, C.;  CHU Saint Luc, Université Catholique de Louvain, Belgium
Pinedo Sierra, C.;  Hospital San Carlos, Madrid, Spain
Pini, L.;  University of Brescia, Spedali Civili di Brescia, Brescia, Italy
Powitz, F.;  Pneumologie Elisenhof München, München, Germany
Ranger, T.;  European Lung Foundation, Sheffield, United Kingdom
Rasmussen, L.;  Copenhagen University Hospital Gentofte, Gentofte, Denmark
Rasmussen, K.;  Zealand University Hospital, Roskilde, Denmark
Rezelj, M.;  University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia
Ricciardi, L.;  University Hospital “G. Martino”, University of Messina, Italy
Ricciardolo, F.;  University of Torino, San Luigi Hospital, Orbassano, Torino, Italy
Ridolo, E.;  University of Parma, Parma, Italy
Rijssenbeek-Nouwens, L.;  Dutch Asthma Centre Davos, Davos, Switzerland
Rolla, G.;  AO Mauriziano Hospital, University of Torino, Turin, Italy
Romero Ribate, D.;  Hospital La Paz, Madrid, Spain
Rüdiger, S.;  Universitätsklinikum Ulm, Ulm, Germany
Safioti, G.;  Teva Pharmaceuticals, Amsterdam, Netherlands
Sandström, T.;  Umeå University, Umeå, Sweden
Santus, P.;  Università degli Studi di Milano, Sacco University Hospital, ASST Fatebenefratelli-Sacco, Milano, Italy
Sauer, R.;  Lungenzentrum Ulm, Ulm, Germany
Schauerte, G.;  CJD Berchtesgaden, Asthmazentrum und Diabeteszentrum, Berchtesgaden, Germany
Schipmann, R.;  Klinik Martinusquelle, Bad Lippspringe, Germany
Schleich, Florence ;  Université de Liège - ULiège > Département des sciences de la motricité > Département des sciences de la motricité
Schmid, J.;  Aarhus University Hospital, Aarhus, Denmark
Schmidt, F.;  Pneumologische Gemeinschaftspraxis Dr Schmidt und Weeg, München, Germany
Schmidt, O.;  Lungenfachärzte KSS, Koblenz, Germany
Schmitz, M.;  Pneumo Westpfalz, Kaiserslautern, Germany
Schrag, T.;  Praxis Dr med. Till Schrag, Bad Reichenhall, Germany
Schröer, S.;  Internistische Schwerpunktpraxis, Villingen-Schwenningen, Germany
Schultz, K.;  Klinik Bad Reichenhall, Bad Reichenhall, Germany
Schulz, C.;  Universitätsklinikum Regensburg, Regensburg, Germany
Scichilone, N.;  University of Palermo, Palermo, Italy
Sedlak, V.;  Czech Pneumology and Phthiseology Society, Prague, Czech Republic
Selb, J.;  University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia
Senna, G.;  University Hospital of Verona, Verona, Italy
Sergejeva, S.;  University of Tartu, Tartu, Estonia
Serrano Pariente, J.;  Hospital Inca, Islas Baleares, Spain
Sichau, M.;  MVZ für Diagnostik und Therapie, Herne, Germany
Simona, D.;  AV3 ASUR Marche, Hospital Civitanova Marche, Macerata, Italy
Singer, A.;  Barts Health NHS Trust, Londo, United Kingdom
Skowasch, D.;  Universitätsklinikum Bonn, Bonn, Germany
Smeenk, F.;  Catharina Hospital, Eindhoven, Netherlands
Smith, S.;  GSK, Durham, NC, United States
Solidoro, P.;  University of Turin, Turin, Italy
Spadaro, G.;  AO Universitaria Federico II, Naples, Italy
Spanevello, A.;  Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy, University of Insubria, Varese, Italy
Stefansdottir, M.;  European Lung Foundation, Sheffield, United Kingdom
Steinmetz, K.;  Gemeinschaftspraxis, Darmstadt, Germany
Steiß, J.;  Universitätsklinikum Giessen, Giessen, Germany
Stephan, M.;  Klinik Löwenstein, Löwenstein, Germany
Stieglitz, S.;  Wuppertaler Lungenzentrum, Wuppertal, Germany
Suhling, H.;  MH Hannover, Hannover, Germany
Taube, C.;  Universitätsmedizin Essen, Westdeutsches Lungenzentrum am Universitätsklinikum Essen gGmbH, Essen, Germany
Tolga Yavuz, S.;  Universitätsklinikum Bonn, Bonn, Germany
Tudoric, N.;  Dubrava University Hospital, Zagreb, Croatia
Ulrik, C.;  Hvidovre University Hospital, Copenhagen, Denmark
van de Ven, M.;  Rijnstate Hospital, Arnhem, Netherlands
van den Elshout, F.;  Rijnstate Hospital, Arnhem, Netherlands
van Dyke, M.;  GSK, Collegeville, PA, United States
van Nederveen-Bendien, S.;  Haga Hospital, The Hague, Netherlands
van Veen, I.;  Medisch Spectrum Twente, Enschede, Netherlands
Vandenplas, O.;  CHU Godine, Namur, Belgium
Velthove, K.;  GSK, Zeist, Netherlands
Vianello, A.;  University of Padova, Padova, Italy
Vogelberg, C.;  Universitätsklinikum Carl Gustav Carus, Klinik und Poliklinik für Kinder- und Jugendmedizin, Dresden, Germany
Wallén-Nielsen, E.;  Division of Respiratory Medicine and Allergy, Dept of Medicine, Karolinska University Hospital, Huddinge, Sweden
Wisskirchen, T.;  Aeroprax, Wuppertal, Germany
Yacoub, M.;  San Raffaele Hospital of Milano, Milan, Italy
Yancey, S.;  GSK, Durham, NC, United States
Zappa, M.;  Sandro Pertini Hospital, Rome, Italy
Zielen, S.;  Universitätsklinikum Frankfurt, Frankfurt, Germany
Zimmermann, C.;  Pneumologische Praxis Reutlingen, Reutlingen, Germany
Zimmermann, R.;  Klinikum Landshut, Medizinische Klinik 2, Landshut, Germany
SHARP Clinical Research Collaboration
More authors (256 more) Less
Language :
English
Title :
Characteristics and treatment regimens across ERS SHARP severe asthma registries
Publication date :
October 2020
Journal title :
European Respiratory Journal
ISSN :
0903-1936
eISSN :
1399-3003
Publisher :
European Respiratory Society
Volume :
55
Issue :
1
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Novartis [BE]
AstraZeneca [BE]
Teva Pharmaceutical Industries
Boehringer Ingelheim [DE]
GSK - GlaxoSmithKline [BE]
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