Instabilité glycémique et anticorps anti-insuline

[fr] L’instabilité glycémique est courante chez les malades traités par insuline et invalidante en raison des hypoglycémies répétées, soudaines, parfois sévères. Les formulations d’insuline actuelles sont moins immunogènes, mais ont une réactivité croisée avec les anticorps anti-insuline développés contre des insulines antérieures. Une résistance à l’insuline acquise inexplicable ou l’association d’hyperglycémies postprandiales et d’hypoglycémies nocturnes sans proportion avec l’insuline administrée sont suggestives de l’implication des anticorps anti-insuline, mais exceptionnelles en dehors de l’insulinothérapie intra-péritonéale. Vu la prédominance de la pratique inadéquate de l’insulinothérapie, l’hypothèse du rôle des anticorps anti-insuline dans l’instabilité glycémique doit être dûment documentée en hospitalisation avant de pouvoir être retenue.

Disciplines :

Endocrinology, metabolism & nutrition

Author, co-author :

Renard, E.; CHU de Montpellier

Radermecker, Régis ; Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques

Scheen, André ; Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale

Language :

French

Title :

Instabilité glycémique et anticorps anti-insuline

Publication date :

October 2008

Journal title :

Médecine des Maladies Métaboliques

ISSN :

1957-2557

eISSN :

2214-8477

Publisher :

Elsevier Masson

Volume :

Issue :

Pages :

531-535

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.em-consulte.com/revue/mmm

Available on ORBi :

since 12 October 2009

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