Article (Scientific journals)
Sickle cell trait among blood donors in the democratic republic of the Congo: which transfusion policy for Sickle cell patients
BATINA AGASA, Salomon; KAMBALE KOMBI, Paul; KABAMBA, Paul et al.
2020In International Society of Blood Transfusion
Peer reviewed
 

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Keywords :
blood donors; Democratic Republic of the Congo; sickle cell trait
Abstract :
[en] Background Prevalence of sickle cell trait is high in the Democratic Republic of Congo (DRC). Blood services, therefore, face the risk of collecting blood units from donors with sickle cell trait. Objective This study aimed to determine the frequency of haemoglobin S among blood donors in Kinshasa. Materials and Methods The study was carried out in the period from 1 January 2014 to 31 December 2015, and 250 blood donors, who gave their consent, were selected using convenience sampling method when donating blood at the National Blood Transfusion Centre in Kinshasa, the Democratic Republic of the Congo. For the testing, blood samples (2 ml) were obtained at the time of blood donation, added to EDTA tubes, mixed and processed within 24 h. The haemoglobin variants were determined by electrophoresis on alkaline agarose gel and confirmed on acid gel. Results Among the 250 blood donors, 20 8 % were female and 79 2%, male. Blood donors in the age range from 25 to 29 years were the most represented, accounting for 23 2%. The youngest donor was 19 years old and the oldest, 58 years old. None of the donors were aware of the HbS status and all have donated previously. According to the haemoglobin variants, 23 6% were confirmed as AS and 76 4%, as AA. Conclusion The proportion of blood donors with HbS is high in the DRC. The possibility of implementing the compulsory routine screening of sickle cell trait (SCT), using sickle cell rapid test, should be explored and the supply of blood units from donors with SCT to patients with sickle cell disease (SCD) should be avoided, whenever possible.
Disciplines :
Hematology
Author, co-author :
BATINA AGASA, Salomon;  Université de Kisangani > Département de Médecine Interne
KAMBALE KOMBI, Paul;  Université de Kisangani > Département de Médecine Interne
KABAMBA, Paul;  Centre National de Transfusion Sanguine, RDC
TONEN-WOLYEC, Serge;  Université de Kisangani > Département de Médecine Interne
KAYEMBE TSHILUMBA, Charles;  Université de Kisangani > Département de Médecine Interne
Marini Djang'Eing'A, Roland ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
KABINDA MAOTELA, Jeef;  Centre National de Transfusion Sanguine, RDC
Language :
English
Title :
Sickle cell trait among blood donors in the democratic republic of the Congo: which transfusion policy for Sickle cell patients
Publication date :
2020
Journal title :
International Society of Blood Transfusion
ISSN :
1751-2824
Peer reviewed :
Peer reviewed
Name of the research project :
DREPAKIS
Funders :
ARES CCD - Académie de Recherche et d'Enseignement Supérieur. Coopération au Développement [BE]
Available on ORBi :
since 04 January 2021

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