Article (Scientific journals)
A review of burn symptoms and potential novel neural targets for non-invasive brain stimulation for treatment of burn sequelae.
Thibaut, Aurore; Shie, Vivian L.; Ryan, Colleen M. et al.
2020In Burns: Journal of the International Society for Burn Injuries
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Keywords :
Non-invasive brain stimulation; Pain; Pruritus; Psychosocial disorders; Transcranial direct current stimulation
Abstract :
[en] Burn survivors experience myriad associated symptoms such as pain, pruritus, fatigue, impaired motor strength, post-traumatic stress, depression, anxiety, and sleep disturbance. Many of these symptoms are common and remain chronic, despite current standard of care. One potential novel intervention to target these post burn symptoms is transcranial direct current stimulation (tDCS). tDCS is a non-invasive brain stimulation (NIBS) technique that modulates neural excitability of a specific target or neural network. The aim of this work is to review the neural circuits of the aforementioned clinical sequelae associated with burn injuries and to provide a scientific rationale for specific NIBS targets that can potentially treat these conditions. We ran a systematic review, following the PRISMA statement, of tDCS effects on burn symptoms. Only three studies matched our criteria. One was a feasibility study assessing cortical plasticity in chronic neuropathic pain following burn injury, one looked at the effects of tDCS to reduce pain anxiety during burn wound care, and one assessed the effects of tDCS to manage pain and pruritus in burn survivors. Current literature on NIBS in burn remains limited, only a few trials have been conducted. Based on our review and results in other populations suffering from similar symptoms as patients with burn injuries, three main areas were selected: the prefrontal region, the parietal area and the motor cortex. Based on the importance of the prefrontal cortex in the emotional component of pain and its implication in various psychosocial symptoms, targeting this region may represent the most promising target. Our review of the neural circuitry involved in post burn symptoms and suggested targeted areas for stimulation provide a spring board for future study initiatives.
Disciplines :
Neurology
Author, co-author :
Thibaut, Aurore ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Shie, Vivian L.
Ryan, Colleen M.
Zafonte, Ross
Ohrtman, Emily A.
Schneider, Jeffrey C.
Fregni, Felipe
Language :
English
Title :
A review of burn symptoms and potential novel neural targets for non-invasive brain stimulation for treatment of burn sequelae.
Publication date :
2020
Journal title :
Burns: Journal of the International Society for Burn Injuries
ISSN :
0305-4179
eISSN :
1879-1409
Publisher :
Elsevier, United Kingdom
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright © 2020. Published by Elsevier Ltd.
Available on ORBi :
since 27 December 2020

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