Median nerve stimulation induced motor learning in healthy adults: A study of timing of stimulation and type of learning

Carvalho, S.; French, M.; Thibaut, Aurore; Lima, W.; Simis, M.; Leite, J.; Fregni, F.

doi:10.1111/ejn.13990

Article (Scientific journals)

Median nerve stimulation induced motor learning in healthy adults: A study of timing of stimulation and type of learning

Carvalho, S.; French, M.; Thibaut, Aurore et al.

2018 • In European Journal of Neuroscience, 48 (1), p. 1667-1679

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10.1111/ejn.13990

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[en] Median nerve stimulation (MNS) has been shown to change brain metaplasticity over the somatosensory networks, based on a bottom-up mechanism and may improve motor learning. This exploratory study aimed to test the effects of MNS on implicit and explicit motor learning as measured by the serial reaction time task (SRTT) using a double-blind, sham-controlled, randomized trial, in which participants were allocated to one of three groups: (a) online active MNS during acquisition, (b) offline active MNS during early consolidation and (c) sham MNS. SRTT was performed at baseline, during the training phase (acquisition period), and 30 min after training. We assessed the effects of MNS on explicit and implicit motor learning at the end of the training/acquisition period and at retest. The group receiving online MNS (during acquisition) showed a significantly higher learning index for the explicit sequences compared to the offline group (MNS during early consolidation) and the sham group. The offline group also showed a higher learning index as compared to sham. Additionally, participants receiving online MNS recalled the explicit sentence significantly more than the offline MNS and sham groups. MNS effects on motor learning have a specific effect on type of learning (explicit vs. implicit) and are dependent on timing of stimulation (during acquisition vs. early consolidation). More research is needed to understand and optimize the effects of peripheral electrical stimulation on motor learning. Taken together, our results show that MNS, especially when applied during the acquisition phase, is a promising tool to modulate motor leaning. © 2018 Federation of European Neuroscience Societies and John Wiley & Sons Ltd

Disciplines :

Neurology

Author, co-author :

Carvalho, S.; Spaulding Neuromodulation Center, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, Neurotherapeutics and Experimental Psychopatology Group, Psychological Neuroscience Laboratory, CIPsi, School of Psychology, University of Minho, Campus de Gualtar, Braga, Portugal

French, M.; Spaulding Neuromodulation Center, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

Thibaut, Aurore ; Université de Liège - ULiège > Consciousness-Coma Science Group

Lima, W.; Spaulding Neuromodulation Center, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

Simis, M.; Instituto de Medicina Fisica e Reabilitacao, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil

Leite, J.; Spaulding Neuromodulation Center, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, Neurotherapeutics and Experimental Psychopatology Group, Psychological Neuroscience Laboratory, CIPsi, School of Psychology, University of Minho, Campus de Gualtar, Braga, Portugal, Univ Portucalense, Portucalense Institute for Human Development – INPP, Oporto, Portugal

Fregni, F.; Spaulding Neuromodulation Center, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

Language :

English

Title :

Median nerve stimulation induced motor learning in healthy adults: A study of timing of stimulation and type of learning

Publication date :

2018

Journal title :

European Journal of Neuroscience

ISSN :

0953-816X

eISSN :

1460-9568

Publisher :

Blackwell Publishing Ltd

Volume :

Issue :

Pages :

1667-1679

Peer reviewed :

Peer Reviewed verified by ORBi

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since 27 December 2020

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