Article (Scientific journals)
Distinct behavioral response of primary motor cortex stimulation in itch and pain after burn injury
Thibaut, Aurore; Ohrtman, E. A.; Morales-Quezada, L. et al.
2019In Neuroscience Letters, 690, p. 89-94
Peer Reviewed verified by ORBi
 

Files


Full Text
Thibaut2019_tDCSburn.pdf
Publisher postprint (388.17 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Burn; Itch; Neuromodulation; Pain; Transcranial direct current stimulation; Article; Brief Pain Inventory
Abstract :
[en] It is still unclear whether chronic neuropathic pain and itch share similar neural mechanisms. They are two of the most commonly reported challenges following a burn injury and can be some of the most difficult to treat. Transcranial direct current stimulation (tDCS) has previously been studied as a method to modulate pain related neural circuits. Therefore, we aimed to test the effects of tDCS on post-burn neuropathic pain and itch as to understand whether this would induce a simultaneous modulation of these two sensory manifestations. We conducted a pilot randomized controlled clinical trial comprised of two phases of active or sham M1 tDCS (Phase I: 10 sessions followed by a follow-up period of 8 weeks; Phase II: additional 5 sessions followed by a follow-up period of 8 weeks, and a final visit 12 months from baseline). Pain levels were assessed with the Brief Pain Inventory (BPI) and levels of itch severity were assessed with the Visual Analogue Scale (VAS). Measurements were collected at baseline, after the stimulation periods, at 2, 4 and 8-week follow up both for Phase I and II, and at the final visit. Sixteen patients were assigned to the active group and 15 to the sham group. Ten sessions of active tDCS did not reduce the level of pain or itch. We identified that itch levels were reduced at 2-week follow-up after the sham tDCS session, while no placebo effect was found for the active group. No difference between active and sham groups was observed for pain. We did not find any treatment effects during Phase II. Based on these findings, it seems that an important placebo effect occurred during sham tDCS for itch, while active M1 tDCS seems to disrupt sensory compensatory mechanisms. We hypothesize that pain and itch are complementary but distinct mechanisms of adaptation after peripheral sensory injury following a burn injury and need to be treated differently. © 2018 Elsevier B.V.
Disciplines :
Neurology
Author, co-author :
Thibaut, Aurore ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Ohrtman, E. A.;  Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, United States
Morales-Quezada, L.;  Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, United States
Simko, L. C.;  Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, United States
Ryan, C. M.;  Massachusetts General Hospital, Harvard Medical School, Boston, MA, Shriners Hospitals for Children-Boston, Boston, MA, United States
Zafonte, R.;  Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, United States, Massachusetts General Hospital and Brigham and Womens Hospital, Boston, United States
Schneider, J. C.;  Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, United States
Fregni, F.;  Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, United States
Language :
English
Title :
Distinct behavioral response of primary motor cortex stimulation in itch and pain after burn injury
Publication date :
2019
Journal title :
Neuroscience Letters
ISSN :
0304-3940
eISSN :
1872-7972
Publisher :
Elsevier Ireland Ltd
Volume :
690
Pages :
89-94
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 December 2020

Statistics


Number of views
75 (1 by ULiège)
Number of downloads
194 (1 by ULiège)

Scopus citations®
 
12
Scopus citations®
without self-citations
8
OpenCitations
 
10

Bibliography


Similar publications



Contact ORBi