Article (Scientific journals)
Targeting chloride transport in autosomal dominant polycystic kidney disease.
Jouret, François; Devuyst, Olivier
2020In Cellular Signalling, 73, p. 109703
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Keywords :
CFTR; Epithelial cell; Ion transport; Kidney cyst; Vasopressin
Abstract :
[en] Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent inherited kidney disease. Transepithelial fluid secretion is one of the key factors of cystogenesis in ADPKD. Multiple studies have suggested that fluid secretion across ADPKD cyst-lining cells is driven by the secretion of chloride, essentially mediated by the CFTR channel and stimulated by increased intracellular levels of 3',5'-cyclic adenosine monophosphate. This review focuses on the pathophysiology of fluid secretion in ADPKD based on the pioneering studies of Jared Grantham and colleagues, and on the follow-up investigations from the molecular level to the potential applications in ADPKD patients. Altogether, the studies of fluid and chloride transport in ADPKD paved the way for innovative therapeutic targets to prevent cyst volume expansion and thus, kidney disease progression.
Disciplines :
Urology & nephrology
Author, co-author :
Jouret, François  ;  Université de Liège - ULiège > Cardiovascular Sc.-Lab. of Translational Res. in Nephrology
Devuyst, Olivier
Language :
English
Title :
Targeting chloride transport in autosomal dominant polycystic kidney disease.
Publication date :
2020
Journal title :
Cellular Signalling
ISSN :
0898-6568
eISSN :
1873-3913
Publisher :
Elsevier, Netherlands
Volume :
73
Pages :
109703
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Available on ORBi :
since 22 December 2020

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