Glomerular filtration rate of black african people: what concordance between MDRD and Cockroft-gault formulas in old and obese poeple

The prevalence of kidney failure is increasing and also affects developing countries. In Africa
particularly in Ivory Coast, in the absence of data on the Modification of Diet in Renal Disease formula
(MDRD), using the Cockcroft-Gault formula (CG) is still valid for estimating renal function, regardless of the
epidemiological and clinical context. The present study aims to compare the CG and MDRD formulas in the
diagnosis of chronic renal failure in black Africans subjects.The study involved 470 adult black Africans. Serum
creatinine was measured by colorimetric Jaffe method and the formula is the MDRD with 4 variables. Analysis
of the collected data was mainly carried out with the EXCEL 2003 software and EPI info 6.04. The comparison
is made by a concordance study from the kappa test.The results showed that in the men and women there is no
difference between the DFG given by the two formulas (P <0,001); diagnostics agree significantly. However,
there is a discrepancy between the results given by both MDRD and CG formulas in the elderly over 65 years (
P = 0,363) and in in Obese subjects ( P = 0,142 ) .Our results show that the choice of the GFR determination
method should be based on context. So it becomes imperative to validate the MDRD method among black
Africans in order to have more methods of determinations, and then choose the most suitable according to the
clinical case for the diagnosis, classification and monitoring of CKD patients.