Les anticorps monoclonaux en hématologie en 2009

Bonnet, Christophe; Beguin, Yves; De Prijck, Bernard; Witvrouw, Nancy; Hustinx, Roland; Fillet, Georges

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Les anticorps monoclonaux en hématologie en 2009

Bonnet, Christophe; Beguin, Yves; De Prijck, Bernard et al.

2009 • In Revue Médicale de Liège, 64, p. 268-273

Peer reviewed

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https://hdl.handle.net/2268/25411

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19642457

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Keywords :

NHL; CLL; Rituximab; 90Y ibritumomab tiuxetan; Alemtuzumab; LNH; LLC

Abstract :

[en] Directed against the CD20 antigen on B lymphocytes, rituximab (MabThera) is now incorporated in the first line therapy of symptomatic follicular as well as diffuse large B cell non-Hodgkin's lymphoma and offers superior response and survival rates. 90Y ibritumomab tiuxetan (Zevalin) combines the specificity of rituximab for the CD20 antigen and the therapeutic effect of β irradiation. Given in monotherapy, it constitutes an interesting alternative therapy for follicular lymphomas in second relapse. Alemtuzumab (MabCampath) recognizes the CD52 antigen and offers encouraging results in chronic lymphocytic leukemia resistant to classical chemotherapy.
[fr] Dirigé contre l'antigène CD20 présent à la surface des lymphocytes de phénotype B, le rituximab (MabThera) fait actuellement partie du traitement de première ligne des lymphomes non-Hodgkigniens folliculaires symptomatiques ainsi que des lymphomes diffus à grandes cellules B. Il permet une amélioration considérable des taux de réponse thérapeutique et de survie. Administré en monothérapie, l'90Y ibritumomab tiuxetan (Zevalin) combine la spécificité de l'anticorps monoclonal à l'encontre de l'antigène CD20 avec le pouvoir thérapeutique des radiations β et constitue une alternative thérapeutique pour les lymphomes folliculaires en deuxième rechute. L'alemtuzumab (MabCampath) reconnaît l'antigène CD52 et offre des résutlats encourageants lors du traitement de la leucémie lymphoïde chronique devenue résistante à la chimiothérapie classique.

Disciplines :

Hematology

Author, co-author :

Bonnet, Christophe ; Université de Liège - ULiège > Département des sciences cliniques > Hématologie - Oncologie médicale

Beguin, Yves ; Université de Liège - ULiège > Département des sciences cliniques > Hématologie - Oncologie médicale

De Prijck, Bernard ; Université de Liège - ULiège > Hématologie clinique

Witvrouw, Nancy ; Université de Liège - ULiège > Médecine nucléaire

Hustinx, Roland ; Université de Liège - ULiège > Département des sciences cliniques > Médecine nucléaire

Fillet, Georges ; Université de Liège - ULiège > Département des sciences cliniques > Hématologie - Oncologie médicale

Language :

French

Title :

Les anticorps monoclonaux en hématologie en 2009

Alternative titles :

[en] Monoclonal antibodies in hematology in 2009

Publication date :

2009

Journal title :

Revue Médicale de Liège

ISSN :

0370-629X

eISSN :

2566-1566

Publisher :

Hopital de Baviere, Liège, Belgium

Volume :

Pages :

268-273

Peer reviewed :

Peer reviewed

Available on ORBi :

since 12 October 2009

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