Cabbage and fermented vegetables: From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19

Bousquet, J.; Anto, J. M.; Czarlewski, W.; Haahtela, T.; Fonseca, S. C.; Iaccarino, G.; Blain, H.; Vidal, Alain; Sheikh, A.; Akdis, C. A.; Zuberbier, T.; Hamzah Abdul Latiff, A.; Abdullah, B.; Aberer, W.; Abusada, N.; Adcock, I.; Afani, A.; Agache, I.; Aggelidis, X.; Agustin, J.; Akdis, M.; Al-Ahmad, M.; Al-Zahab Bassam, A.; Alburdan, H.; Aldrey-Palacios, O.; Alvarez Cuesta, E.; Alwan Salman, H.; Alzaabi, A.; Amade, S.; Ambrocio, G.; Angles, R.; Annesi-Maesano, I.; Ansotegui, I. J.; Anto, J.; Ara Bardajo, P.; Arasi, S.; Arshad, H.; Cristina Artesani, M.; Asayag, E.; Avolio, F.; Azhari, K.; Bachert, C.; Bagnasco, D.; Baiardini, I.; Bajrović, N.; Bakakos, P.; Bakeyala Mongono, S.; Balotro-Torres, C.; Barba, S.; Barbara, C.; Barbosa, E.; Barreto, B.; Bartra, J.; Bateman, E. D.; Battur, L.; Bedbrook, A.; Bedolla Barajas, M.; Beghé, B.; Bekere, A.; Bel, E.; Ben Kheder, A.; Benson, M.; Berghea, E. 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doi:10.1111/all.14549

Article (Scientific journals)

Cabbage and fermented vegetables: From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19

Bousquet, J.; Anto, J. M.; Czarlewski, W. et al.

2021 • In Allergy

Peer reviewed

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https://hdl.handle.net/2268/253923

DOI
10.1111/all.14549

PubMed
32762135

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Keywords :

COVID-19; Lactobacillus

Abstract :

[en] Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT1R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT1R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity. © 2020 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

Disciplines :

Cardiovascular & respiratory systems

Author, co-author :

Bousquet, J.; Charité, Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin, Germany, Department of Dermatology and Allergy, Berlin Institute of Health, Comprehensive Allergy Center, Berlin, Germany, MACVIA-France and CHU, Montpellier, France

Anto, J. M.; Centre for Research in Environmental Epidemiology (CREAL), ISGlobAL, Barcelona, Spain, IMIM (Hospital del Mar Research Institute), Barcelona, Spain, Universitat Pompeu Fabra (UPF), Barcelona, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain

Czarlewski, W.; MASK-Air, Montpellier, France, Medical Consulting Czarlewski, Levallois, France

Haahtela, T.; Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Finland

Fonseca, S. C.; Faculty of Sciences, GreenUPorto - Sustainable Agrifood Production Research Centre, DGAOT, University of Porto, Porto, Portugal

Iaccarino, G.; Department of Advanced Biomedical Sciences, Federico II University, Napoli, Italy

Blain, H.; Department of Geriatrics, Montpellier University hospital and MUSE, Montpellier, France

Vidal, Alain

Sheikh, A.; Usher Institute, University of Edinburgh, United Kingdom

Akdis, C. A.; Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland

More authors (649 more)

Language :

English

Title :

Cabbage and fermented vegetables: From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19

Publication date :

2021

Journal title :

Allergy

ISSN :

0105-4538

eISSN :

1398-9995

Publisher :

Blackwell Publishing Ltd

Peer reviewed :

Peer reviewed

Additional URL :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436771/pdf/ALL-9999-na.pdf

Available on ORBi :

since 11 December 2020

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