Article (Scientific journals)
Invasive group B Streptococcus among non-pregnant adults in Brussels-Capital Region, 2005–2019
Graux, Elena; Hites, Maya; Martiny, Delphine et al.
2020In European Journal of Clinical Microbiology and Infectious Diseases, p. 1-9
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Keywords :
Group B streptococcus; Non-pregnant adults; Invasive infections; Incidence; Serotypes; Vaccine; Obesity
Abstract :
[en] To assess the incidence, clinical, microbiological features and outcome of invasive Streptococcus agalactiae (GBS) infections in non-pregnant adults in three tertiary hospitals of the Brussels-Capital Region. All bacterial cultures positive for GBS, from 2005 to 2019 from 3 hospitals of the Brussels-Capital Region, were extracted, and only cases of invasive diseases were included. Medical files were retrospectively retrieved for risk factors, clinical manifestations and outcome and also antibiotic-susceptibility testing and GBS serotypes. Incidence rates were calculated based on the hospitals catchment populations. A total of 337 cases of GBS-invasive infections were included. The incidence of invasive GBS for the 3 hospitals increased from 3.7 to 8.2 cases per 100.000 inhabitants between 2009 and 2018 (p = 0.04). The most frequently identified risk factors were diabetes (36.8%), obesity (35.0%), cancer (21.7%), renal disease (20.8%), and advanced age (≥ 65 years; 47.2%). Isolated bacteremia (22%), osteoarticular infection (21.4%), abscesses (13.9%), and skin and soft tissue infections (18.4%) were the most frequent manifestations. Intensive care unit admission was required in 21.7% and overall mortality was 9.4%. All strains remained susceptible to penicillin over the years. Up to 20% of strains were resistant to clindamycin. Serotypes Ia, Ib, II, III, IV, and V represented 96.8% of the available serotypes (60/62). As reported in several countries, invasive GBS disease in non-pregnant adults represents an increas- ing burden, particularly among diabetic, obese, and elderly patients. Almost all serotypes identified are included in the upcoming hexavalent GBS conjugate vaccine.
Disciplines :
Laboratory medicine & medical technology
Immunology & infectious disease
Author, co-author :
Graux, Elena;  Centre Hospitalier Universitaire Saint-Pierre (Bruxelles) - CHU St-Pierre > Infectious diseases
Hites, Maya;  Cliniques Universitaires de Bruxelles - Hôpital Erasme > Clinic of Infectious diseases
Martiny, Delphine;  Hopitaux universitaires de Bruxelles > Laboratoire
Maillart, Evelyne;  Centre hospitalier universitaire Brugman > Infectious diseases
Delforge, Marc;  Centre Hospitalier Universitaire Saint-Pierre (Bruxelles) - CHU St-Pierre > Infectious diseases
MELIN, Pierrette  ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Service de microbiologie clinique
Dauby, Nicolas;  Centre Hospitalier Universitaire Saint-Pierre (Bruxelles) - CHU St-Pierre > Infectious diseases
Language :
English
Title :
Invasive group B Streptococcus among non-pregnant adults in Brussels-Capital Region, 2005–2019
Publication date :
17 September 2020
Journal title :
European Journal of Clinical Microbiology and Infectious Diseases
ISSN :
0934-9723
eISSN :
1435-4373
Publisher :
Springer, Germany
Pages :
1-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 07 December 2020

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