Article (Scientific journals)
Peer-reviewed and unbiased research, rather than 'sound science', should be used to evaluate endocrine-disrupting chemicals
Trasande, L.; Vandenberg, L. N.; Bourguignon, Jean-Pierre et al.
2016In Journal of Epidemiology and Community Health, 70 (11), p. 1051-1056
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Keywords :
Peer review; Endocrinology; Environmental health; Environmental epidemiology; Toxicology; Endocrine disruptors
Abstract :
[en] Evidence increasingly confirms that synthetic chemicals disrupt the endocrine system and contribute to disease and disability across the lifespan. Despite a United Nations Environment Programme/WHO report affirmed by over 100 countries at the Fourth International Conference on Chemicals Management, 'manufactured doubt' continues to be cast as a cloud over rigorous, peer-reviewed and independently funded scientific data. This study describes the sources of doubt and their social costs, and suggested courses of action by policymakers to prevent disease and disability. The problem is largely based on the available data, which are all too limited. Rigorous testing programmes should not simply focus on oestrogen, androgen and thyroid. Tests should have proper statistical power. 'Good laboratory practice' (GLP) hardly represents a proper or even gold standard for laboratory studies of endocrine disruption. Studies should be evaluated with regard to the contamination of negative controls, responsiveness to positive controls and dissection techniques. Flaws in many GLP studies have been identified, yet regulatory agencies rely on these flawed studies. Peer-reviewed and unbiased research, rather than 'sound science', should be used to evaluate endocrine-disrupting chemicals.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Trasande, L.;  Department of Pediatrics, New York University School of Medicine, New York, NY, United States, Department of Environmental Medicine and Population Health, New York University School of Medicine, New York, NY, United States, Department of Population Health, New York University School of Medicine, New York, NY, United States, NYU Wagner School of Public Service, New York, NY, United States, Department of Nutrition, Food and Public Health, NYU Steinhardt School of Culture, Education and Human Development, New York, NY, United States, NYU Global Institute of Public Health, New York, NY, United States
Vandenberg, L. N.;  Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts-Amherst, Amherst, MA, United States
Bourguignon, Jean-Pierre ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Myers, J. P.;  Environmental Health Sciences, Charlottesville, VA, United States
Slama, R.;  Inserm, CNRS and Univ. Grenoble Alpes joint research center (IAB), Team of Environmental Epidemiology, Grenoble, France
vom Saal, F.;  Division of Biological Sciences, University of Missouri-Columbia, Columbia, MO, United States
Zoeller, R. T.;  Department of Biology, University of Massachusetts, Amherst, MA, United States
Language :
English
Title :
Peer-reviewed and unbiased research, rather than 'sound science', should be used to evaluate endocrine-disrupting chemicals
Publication date :
2016
Journal title :
Journal of Epidemiology and Community Health
ISSN :
0143-005X
eISSN :
1470-2738
Publisher :
BMJ Publishing Group
Volume :
70
Issue :
11
Pages :
1051-1056
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
NIEHS - National Institute of Environmental Health Sciences [US-NC] [US-NC]
NIH - National Institutes of Health [US-MD] [US-MD]
Wallace Genetic Foundation - WGF
Broad Reach Fund
Fund for the Carolinas
Marisla Foundation
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