[en] Orbitofrontal metabolic impairment is characteristic of the frontal variant of frontotemporal dementia (fv-FTD), as are early changes in emotional and social conduct. Two main types of behavioral disturbances have been distinguished in fv-FTD patients: apathetic and disinhibited manifestations. In this study, we searched for relationships between brain metabolism and presence of apathetic or disinhibited behavior. Metabolic activity and behavioral data were collected in 41 fv-FTD patients from European PET centers. A conjunction analysis of the PET data showed an expected impairment of metabolic activity in the anterior cingulate, ventromedial and orbital prefrontal cortex, the dorsolateral prefrontal cortex and the left anterior insula in fv-FTD subjects compared to matched controls. A correlation was observed between disinhibition scores on the Neuropsychiatric Inventory scale and a cluster of voxels located in the posterior orbitofrontal cortex ( 6, 28, - 24). Comparison of brain activity between apathetic and nonapathetic fv-FTD patients from two centers also revealed a specific involvement of the posterior orbitofrontal cortex in apathetic subjects ( 4, 22, - 22). The results confirm that the main cerebral metabolic impairment in fv-FTD patients affects areas specializing in emotional evaluation and demonstrate that decreased orbitofrontal activity is related to both disinhibited and apathetic syndromes in fv-FTD. Copyright (C) 2006 S. Karger AG, Basel.
Research Center/Unit :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurology Geriatrics Sociology & social sciences
Author, co-author :
Peters, Frederic; Université de Liège - ULiège > Centre de Recherches du Cyclotron
Perani, Daniela
Herholz, Karl
Holthoff, VVjera
Beuthien-Baumann, Bettina
Sorbi, Sandro
Pupi, Alberto
Degueldre, Christian ; Université de Liège - ULiège > Centre de recherches du cyclotron
Lemaire, Christian ; Université de Liège - ULiège > Centre de recherches du cyclotron
Collette, Fabienne ; Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie
Salmon, Eric ; Université de Liège - ULiège > Centre de Recherches du Cyclotron > Département des sciences cliniques -Neuroimagerie des troubles de la mémoire et révalid. cogn.
Language :
English
Title :
Orbitofrontal dysfunction related to both apathy and disinhibition in frontotemporal dementia
EC - European Commission F.R.S.-FNRS - Fonds de la Recherche Scientifique FMRE - Fondation Médicale Reine Elisabeth BELSPO - Politique scientifique fédérale
Funding text :
This study was conducted on behalf of the Network for Efficiency and Standardization of Dementia Diagnosis (NEST-DD), supported by the European Commission (5th framework). The work in Liège is supported by grants from the FNRS, FMRE and IUAP P5/04. FC is a researcher at the FNRS.
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Bibliography
Constantinidis J, Richard J, Tissot R: Pick's disease. Histological and clinical correlations. Eur Neurol 1974;11:208-217.
Neary D, Snowden JS, Gustafson L, Passant U, Stuss D, et al: Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 1998;51:1546-1554.
Hodges JR, Patterson K, Ward R, Garrard P, Bak T, et al: The differentiation of semantic dementia and frontal lobe dementia (temporal and frontal variants of frontotemporal dementia) from early Alzheimer's disease: a comparative neuropsychological study. Neuropsychology 1999;13:31-40.
Ibach B, Poljansky S, Barta W, Koller M, Wittmann M, et al: Patterns of referring of patients with frontotemporal lobar degeneration to psychiatric in- and out-patient services. Results from a prospective multicentre study. Dement Geriatr Cogn Disord 2004;17:269-273.
Chan D, Fox NC, Jenkins R, Scahill RI, Crum WR, et al: Rates of global and regional cerebral atrophy in AD and frontotemporal dementia. Neurology 2001;57:1756-1763.
Rosen HJ, Hartikainen KM, Jagust W, Kramer JH, Reed BR, et al: Utility of clinical criteria in differentiating frontotemporal lobar degeneration (FTLD) from AD. Neurology 2002;58:1608-1615.
Diehl J, Grimmer T, Drzezga A, Riemenschneider M, Forstl H, et al: Cerebral metabolic patterns at early stages of frontotemporal dementia and semantic dementia. A PET study. Neurobiol Aging 2004;25:1051-1056.
Rosen HJ, Gorno-Tempini ML, Goldman WP, Perry RJ, Schuff N, et al: Patterns of brain, atrophy in frontotemporal dementia and semantic dementia. Neurology 2002;58:198-208.
Galton CJ, Patterson K, Graham K, Lambon-Ralph MA, Williams G, et al: Differing patterns of temporal atrophy in Alzheimer's disease and semantic dementia. Neurology 2001;57:216-225.
Nestor PJ, Graham NL, Fryer TD, Williams GB, Patterson K, et al: Progressive non-fluent aphasia is associated with hypometabolism centred on the left anterior insula. Brain 2003;126:2406-2418.
Rosen HJ, Kramer JH, Gorno-Tempini ML, Schuff N, Weiner M, et al: Patterns of cerebral atrophy in primary progressive aphasia. Am J Geriatr Psychiatry 2002;10:89-97.
McKhann GM, Albert MS, Grossman M, Miller B, Dickson D, et al: Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick's Disease. Arch Neurol 2001;58:1803-1809.
Liu W, Miller BL, Kramer JH, Rankin K, Wyss-Coray C, et al: Behavioral disorders in the frontal and temporal variants of frontotemporal dementia. Neurology 2004;62:742-748.
Salmon E, Garraux G, Delbeuck X, Collette F, Kalbe E, et al: Predominant ventromedial frontopolar metabolic impairment in frontotemporal dementia. Neuroimage 2003;20:435-440.
Grimmer T, Diehl J, Drzezga A, Forstl H, Kurz A: Region-specific decline of cerebral glucose metabolism in patients with frontotemporal dementia: a prospective 18F-FDG-PET study. Dement Geriatr Cogn Disord 2004;18:32-36.
Robert PH, Clairet S, Benoit M, Koutaich J, Bertogliati C, et al: The apathy inventory: assessment of apathy and awareness in Alzheimer's disease, Parkinson's disease and mild cognitive impairment. Int J Geriatr Psychiatry 2002;17:1099-1105.
Sarazin M, Pillon B, Giannakopoulos P, Rancurel G, Samson Y, et al: Clinicometabolic dissociation of cognitive functions and social behavior in frontal lobe lesions. Neurology 1998;51:142-148.
Sarazin M, Michon A, Pillon B, Samson Y, Canuto A, et al: Metabolic correlates of behavioral and affective disturbances in frontal lobe pathologies. J Neurol 2003;250:827-833.
Franceschi M, Anchisi D, Pelati O, Zuffi M, Matarrese M, et al: Glucose metabolism and serotonin receptors in the frontotemporal lobe degeneration. Ann Neurol 2005;57:216-225.
Lund and Manchester Groups: Clinical and neuropathological criteria for frontotemporal dementia. The Lund and Manchester Groups. J Neurol Neurosurg Psychiatry 1994;57:416-418.
Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL: A new clinical scale for the staging of dementia. Br J Psychiatry 1982;140:566-572.
Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, et al: The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994;44:2308-2314.
Herholz K, Salmon E, Perani D, Baron JC, Holthoff V, et al: Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET. Neuroimage 2002;17:302-316.
Folstein MF, Robins LN, Helzer JE: The Mini-Mental State Examination. Arch Gen Psychiatry 1983;40:812.
Rosen HJ, Narvaez JM, Hallam B, Kramer JH, Wyss-Coray C, et al: Neuropsychological and functional measures of severity in Alzheimer disease, frontotemporal dementia, and semantic dementia. Alzheimer Dis Assoc Disord 2004;18:202-207.
Salmon E, Lespagnard P, Marique P, Peters F, Herholz K, et al: Cerebral metabolic correlates of four dementia scales in Alzheimer's disease. J Neurol 2005;252:1138.
Cummings JL: Frontal-subcortical circuits and human behavior. Arch Neurol 1993;50:873-880.
Starkstein SE, Robinson RG: Mechanism of disinhibition after brain lesions. J Nerv Ment Dis 1997;185:108-114.
Rolls ET: The orbitofrontal cortex and reward. Cereb Cortex 2000;10:284-294.
Hornak J, O'Doherty J, Bramham J, Rolls ET, Morris RG, et al: Reward-related reversal learning after surgical excisions in orbito-frontal or dorsolateral prefrontal cortex in humans. J Cogn Neurosci 2004;16:463-478.
Thut G, Schultz W, Roelcke U, Nienhusmeier M, Missimer J, et al: Activation of the human brain by monetary reward. Neuroreport 1997;8:1225-1228.
Elliott R, Friston KJ, Dolan RJ: Dissociable neural responses in human reward systems. J Neurosci 2000;20:6159-6165.
O'Doherty J, Kringelbach ML, Rolls ET, Hornak J, Andrews C: Abstract reward and punishment representations in the human orbitofrontal cortex. Nat Neurosci 2001;4:95-102.
Bogousslavsky J, Ferrazzini M, Regli F, Assal G, Tanabe H, et al: Manic delirium and frontal-like syndrome with paramedian infarction of the right thalamus. J Neurol Neurosurg Psychiatry 1988;51:116-119.
Similar publications
Sorry the service is unavailable at the moment. Please try again later.
This website uses cookies to improve user experience. Read more
Save & Close
Accept all
Decline all
Show detailsHide details
Cookie declaration
About cookies
Strictly necessary
Performance
Strictly necessary cookies allow core website functionality such as user login and account management. The website cannot be used properly without strictly necessary cookies.
This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.
Performance cookies are used to see how visitors use the website, eg. analytics cookies. Those cookies cannot be used to directly identify a certain visitor.
Used to store the attribution information, the referrer initially used to visit the website
Cookies are small text files that are placed on your computer by websites that you visit. Websites use cookies to help users navigate efficiently and perform certain functions. Cookies that are required for the website to operate properly are allowed to be set without your permission. All other cookies need to be approved before they can be set in the browser.
You can change your consent to cookie usage at any time on our Privacy Policy page.
