Molecular Basis Associated with the Control of Primordial Follicle Activation During Transplantation of Cryopreserved Ovarian Tissue

Terren, Carmen; Munaut, Carine

doi:10.1007/s43032-020-00318-z

Article (Scientific journals)

Molecular Basis Associated with the Control of Primordial Follicle Activation During Transplantation of Cryopreserved Ovarian Tissue

Terren, Carmen; Munaut, Carine

2021 • In Reproductive Sciences, 28, p. 1257-1266

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/253692

DOI
10.1007/s43032-020-00318-z

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32989631

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Keywords :

Cryopreservation; Fertility preservation; Follicular activation; Signalling pathways; Transplantation

Abstract :

[en] Cryopreservation and transplantation of ovarian tissue represent a promising fertility preservation technique for prepubertal patients or for patients requiring urgent oncological management. However, this technique has some limitations, including follicular loss directly after transplantation mainly due to ischaemic damage but also due to activation of primordial follicles (also known as follicular burnout), leading to follicular reserve loss in the graft and thereby potentially reducing its lifespan. In vitro and in vivo studies indicate that the phosphatidylinositol-3-kinase (PI3K)/phosphatase and tensin homologue (PTEN)/Akt, mammalian target of rapamycin (mTOR), c-Jun-N-terminal kinase (JNK), and Hippo signalling pathways are involved in primordial follicle activation. Here, we review the basic mechanisms linked to the follicle activation that occurs after cryopreservation and transplantation of ovarian tissue. A better understanding of the crosstalk between the different signalling pathways may lead to potential improvement of fertility restoration by extending graft lifespan through selective control of the activation of dormant follicles after transplantation of cryopreserved ovarian tissue.

Disciplines :

Reproductive medicine (gynecology, andrology, obstetrics)

Author, co-author :

Terren, Carmen ; Université de Liège - ULiège > GIGA

Munaut, Carine ; Université de Liège - ULiège > Cancer-Tumours and development biology

Language :

English

Title :

Molecular Basis Associated with the Control of Primordial Follicle Activation During Transplantation of Cryopreserved Ovarian Tissue

Publication date :

2021

Journal title :

Reproductive Sciences

ISSN :

1933-7191

eISSN :

1933-7205

Publisher :

SAGE Publications, New York, United States - New York

Volume :

Pages :

1257-1266

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 02 December 2020

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