(2013) State of the Science of Endocrine Disrupting Chemicals—2012
World Health Organisation, , Geneva, Switzerland
(2002) Global Assessment of the State-Of-The-Science of Endocrine Disruptors
International Programme on Chemical Safety
World Health Organisation and United Nations Environment Programme
World Health Organisation, , Geneva, Switzerland
Toppari, J., Virtanen, H.E., Main, K.M., Skakkebaek, N.E., Cryptorchidism and hypospadias as a sign of testicular dysgenesis syndrome (TDS): Environmental connection (2010) Birth Defects Res. a Clin. Mol. Teratol., 88, pp. 910-919
Buck Louis, G., Cooney, M., Peterson, C., The ovarian dysgenesis syndrome (2011) J. Dev. Orig. Health Dis., 2, pp. 25-35
OECD. Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption. OECD Series on Testing and Assessment, No. 150, OECD Publishing, Paris. Avaliable online: https://doi.org/10.1787/9789264304741-en (accessed on 30 April 2020)
Hu, Y., Wen, S., Yuan, D., Peng, L., Zeng, R., Yang, Z., Liu, Q., Kang, D., The association between the environmental endocrine disruptor bisphenol A and polycystic ovary syndrome: A systematic review and meta-analysis (2018) Gynecol. Endocrinol., 34, pp. 370-377
Vagi, S.J., Azziz-Baumgartner, E., Sjodin, A., Calafat, A.M., Dumesic, D., Gonzalez, L., Kato, K., Azziz, R., Exploring the potential association between brominated diphenyl ethers, polychlorinated biphenyls, organochlorine pesticides, perfluorinated compounds, phthalates, and bisphenol A in polycystic ovary syndrome: A case-control study (2014) BMC Endocr. Disord., 14
Vabre, P., Gatimel, N., Moreau, J., Gayrard, V., Picard-Hagen, N., Parinaud, J., Leandri, R.D., Environmental pollutants, a possible etiology for premature ovarian insufficiency: A narrative review of animal and human data (2017) Environ. Health, 16
Viguie, C., Mhaouty-Kodja, S., Habert, R., Chevrier, C., Michel, C., Pasquier, E., Evidence-based adverse outcome pathway approach for the identification of BPA as en endocrine disruptor in relation to its effect on the estrous cycle (2018) Mol. Cell Endocrinol., 475, pp. 10-28
Conlon, J.L., Diethylstilbestrol: Potential health risks for women exposed in utero and their offspring (2017) JAAPA, 30, pp. 49-52
Titus, L., Hatch, E.E., Drake, K.M., Parker, S.E., Hyer, M., Palmer, J.R., Strohsnitter, W.C., Huo, D., Reproductive and hormone-related outcomes in women whose mothers were exposed in utero to diethylstilbestrol (DES): A report from the US National Cancer Institute DES Third Generation Study (2019) Reprod. Toxicol., 84, pp. 32-38
Wallace, W.H., Kelsey, T.W., Human ovarian reserve from conception to the menopause (2010) Plos ONE, 5
Wagner, M., Yoshihara, M., Douagi, I., Damdimopoulos, A., Panula, S., Petropoulos, S., Lu, H., Katayama, S., Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells (2020) Nat. Commun., 11, pp. 1-15
Johansson, H.K.L., Svingen, T., Fowler, P.A., Vinggaard, A.M., Boberg, J., Environmental influences on ovarian dysgenesis—Developmental windows sensitive to chemical exposures (2017) Nat. Rev. Endocrinol., 13, pp. 400-414
Carpenter, T., Grecian, S.M., Reynolds, R.M., Sex differences in early-life programming of the hypothalamic-pituitary-adrenal axis in humans suggest increased vulnerability in females: A systematic review (2017) J. Dev. Orig. Health Dis., 8, pp. 244-255
Pinto, C.L., Markey, K., Dix, D., Browne, P., Identification of candidate reference chemicals for in vitro steroidogenesis assays (2018) Toxicol. Vitr., 47, pp. 103-119
Roelofs, M.J., Piersma, A.H., van den Berg, M., van Duursen, M.B., The relevance of chemical interactions with CYP17 enzyme activity: Assessment using a novel in vitro assay (2013) Toxicol. Appl. Pharm., 268, pp. 309-317
Franssen, D., Ioannou, Y.S., Alvarez-Real, A., Gerard, A., Mueller, J.K., Heger, S., Bourguignon, J.P., Parent, A.S., Pubertal timing after neonatal diethylstilbestrol exposure in female rats: Neuroendocrine vs peripheral effects and additive role of prenatal food restriction (2014) Reprod. Toxicol., 44, pp. 63-72
Franssen, D., Gerard, A., Hennuy, B., Donneau, A.F., Bourguignon, J.P., Parent, A.S., Delayed Neuroendocrine Sexual Maturation in Female Rats After a Very Low Dose of Bisphenol A Through Altered GABAergic Neurotransmission and Opposing Effects of a High Dose (2016) Endocrinology, 157, pp. 1740-1750
Kasper-Sonnenberg, M., Wittsiepe, J., Wald, K., Koch, H.M., Wilhelm, M., Pre-pubertal exposure with phthalates and bisphenol A and pubertal development (2017) Plos One, 12
Rasier, G., Parent, A.S., Gerard, A., Lebrethon, M.C., Bourguignon, J.P., Early maturation of gonadotropin-releasing hormone secretion and sexual precocity after exposure of infant female rats to estradiol or dichlorodiphenyltrichloroethane (2007) Biol. Reprod., 77, pp. 734-742
Parent, A.S., Franssen, D., Fudvoye, J., Gerard, A., Bourguignon, J.P., Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents (2015) Front. Neuroendocr., 38, pp. 12-36
Greenspan, L.C., Lee, M.M., Endocrine disrupters and pubertal timing (2018) Curr Opin Endocrinol Diabetes Obes, 25, pp. 49-54
Binder, A.M., Corvalan, C., Pereira, A., Calafat, A.M., Ye, X., Shepherd, J., Michels, K.B., Prepubertal and Pubertal Endocrine-Disrupting Chemical Exposure and Breast Density among Chilean Adolescents (2018) Cancer Epidemiol. Biomark. Prev., 27, pp. 1491-1499
Wolff, M.S., Teitelbaum, S.L., McGovern, K., Pinney, S.M., Windham, G.C., Galvez, M., Pajak, A., Kushi, L.H., Environmental phenols and pubertal development in girls (2015) Environ. Int., 84, pp. 174-180
Acevedo, N., Davis, B., Schaeberle, C.M., Sonnenschein, C., Soto, A.M., Perinatally administered bisphenol a as a potential mammary gland carcinogen in rats (2013) Environ. Health Perspect., 121, pp. 1040-1046
Mandrup, K., Boberg, J., Isling, L.K., Christiansen, S., Hass, U., Low-dose effects of bisphenol A on mammary gland development in rats (2016) Andrology, 4, pp. 673-683
Marti, N., Galvan, J.A., Pandey, A.V., Trippel, M., Tapia, C., Muller, M., Perren, A., Fluck, C.E., Genes and proteins of the alternative steroid backdoor pathway for dihydrotestosterone synthesis are expressed in the human ovary and seem enhanced in the polycystic ovary syndrome (2017) Mol. Cell Endocrinol., 441, pp. 116-123
Moenter, S.M., Silveira, M.A., Wang, L., Adams, C., Central aspects of systemic oestradiol negative-and positive-feedback on the reproductive neuroendocrine system (2020) J. Neuroendocr., 32
Gal, M., Orly, J., Ketoconazole inhibits ovulation as a result of arrest of follicular steroidogenesis in the rat ovary (2014) Clin. Med. Insights Reprod. Health, 8, pp. 37-44
Parsanezhad, M.E., Alborzi, S., Pakniat, M., Schmidt, E.H., A double-blind, randomized, placebo-controlled study to assess the efficacy of ketoconazole for reducing the risk of ovarian hyperstimulation syndrome (2003) Fertil. Steril., 80, pp. 1151-1155
Bjorvang, R.D., Damdimopoulou, P., Persistent environmental endocrine-disrupting chemicals in ovarian follicular fluid and in vitro fertilization treatment outcome in women (2020) Upsala J. Med. Sci, , 10.1080/03009734.2020.1727073, 1-10
O'shaughnessy, P.J., Antignac, J.P., Le Bizec, B., Morvan, M.L., Svechnikov, K., Soder, O., Savchuk, I., Johnston, Z.C., Alternative (Backdoor) androgen production and masculinization in the human fetus (2019) Plos Biol, 17
Craig, Z.R., Wang, W., Flaws, J.A., Endocrine-disrupting chemicals in ovarian function: Effects on steroidogenesis, metabolism and nuclear receptor signaling (2011) Reproduction, 142, pp. 633-646
Petro, E.M., Leroy, J.L., Covaci, A., Fransen, E., de Neubourg, D., Dirtu, A.C., de Pauw, I., Bols, P.E., Endocrine-disrupting chemicals in human follicular fluid impair in vitro oocyte developmental competence Hum. Reprod, 27, pp. 1025-1033. , doi:10.1093/humrep/der448, 201.2
Petro, E.M.L., D'hollander, W., Covaci, A., Bervoets, L., Fransen, E., de Neubourg, D., de Pauw, I., Bols, P.E.J., Perfluoroalkyl acid contamination of follicular fluid and its consequence for in vitro oocyte developmental competence (2014) Sci. Total Environ., 496, pp. 282-288
Darde, T.A., Gaudriault, P., Beranger, R., Lancien, C., Caillarec-Joly, A., Sallou, O., Bonvallot, N., Jegou, B., TOXsIgN: A cross-species repository for toxicogenomic signatures (2018) Bioinformatics, 34, pp. 2116-2122
Guidance for the identification of endocrine disruptors in the context of Regulations (EU) (2018) No 528/2012 and (EC) No 1107/2009. EFSA J, 16
Montévil, A.R., Acevedo, N., Schaeberle, C., Bharadwai, M., Fenton, S.E., Soto, A.M., A combined morphometric and statistical approach to assess non-monotonicity in the developing mammary gland of rats in the CLARITY-BPA study (2020) Environ. Health Perspect., , Accepted for publication
Drummond, A.E., Fuller, P.J., The importance of ERbeta signalling in the ovary (2010) J. Endocrinol., 205, pp. 15-23
Heublein, S., Lenhard, M., Vrekoussis, T., Schoepfer, J., Kuhn, C., Friese, K., Makrigiannakis, A., Jeschke, U., The G-protein-coupled estrogen receptor (GPER) is expressed in normal human ovaries and is upregulated in ovarian endometriosis and pelvic inflammatory disease involving the ovary (2012) Reprod. Sci., 19, pp. 1197-1204
Tang, Z.R., Zhang, R., Lian, Z.X., Deng, S.L., Yu, K., Estrogen-Receptor Expression and Function in Female Reproductive Disease (2019) Cells, 8
Santos, R.R., Schoevers, E.J., Roelen, B.A., Usefulness of bovine and porcine IVM/IVF models for reproductive toxicology (2014) Reprod. Biol. Endocrinol., 12, p. 117
Demeneix, B., Slama, R., (2019) Endocrine Disruptors: From Scientific Evidence to Human Health Protection, , http://www.europarl.europa.eu/supporting-analyses, Available online:, (accessed on 30 April 2020)