[en] Endocrine disruptors are defined by WHO as “exogenous compounds or mixtures that alter function(s) of the endocrine system and consequently cause adverse effects in an intact organism, or its progeny, or (sub)populations”.1 European Union (EU) laws on pesticides (plant protection products regulation [PPPR]) and biocide products regulation (BPR), enacted in 2009 and 2012, respectively, place restrictions on the use of active substances with severe forms of toxicity, including carcinogenicity, mutagenicity, reproductive toxicity, and endocrine disruption.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Bourguignon, Jean-Pierre ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Slama, R.; Inserm, CNRS and University Grenoble Alpes, IAB Joint Research Center, Team of Environmental Epidemiology, Grenoble, France
Bergman, Å.; Swedish Toxicology Sciences Research Center, Södertälje, Sweden
Demeneix, B.; UMR CNRS/MNHN 7221, Department RDDM, Muséum National d'Histoire Naturelle, Paris, France
Ivell, R.; School of Biosciences & School of Veterinary Medicine and Science, University of Nottingham, Nottingham, United Kingdom
Kortenkamp, A.; Brunel University London, Institute of Environment, Health and Societies, Uxbridge, United Kingdom
Panzica, G.; Department of Neuroscience, University of Torino, Neuroscience Institute Cavalieri Ottolenghi, Orbassano, Italy
Trasande, L.; Departments of Pediatrics, Environmental Medicine and Population health, New York University School of Medicine, New York, NY, United States
Zoeller, R. T.; University of Massachusetts, Biology Department, Amherst, MA, United States
Language :
English
Title :
Science-based regulation of endocrine disrupting chemicals in Europe: which approach?
1 WHO. Global assessment of the state-of-the-science of endocrine disruptors. WHO/PCS/EDC/02.2. http://www.who.int/ipcs/publications/new_issues/endocrine_disruptors/en/ (accessed June 2, 2016).
2 Slama, R, Bourguignon, JP, Demeneix, B, Ivell, R, Panzica, GC, Kortenkamp, A, Zoeller, RT, Scientific issues relevant to setting regulatory criteria to identify endocrine disrupting substances in the European Union. Env Health Perspect, 2016, 10.1289/EHP217 published online April 25.
3 Horel, S, A toxic affair: how the chemical lobby blocked action on endocrine disrupting chemicals, 2015, Corporate Europe Observatory, Brussels http://corporateeurope.org/food-and-agriculture/2015/05/toxic-affair-how-chemical-lobby-blocked-action-hormone-disrupting (accessed June 2, 2016).
4 European Parliament resolution of 8 June 2016 on endocrine disruptors: state of play following the judgment of the General Court of the European Union of 16 December 2015 (2016/2747(RSP). http://www.europarl.europa.eu/sides/getDoc.do?pubRef=-//EP//TEXT+TA+P8-TA-2016-0270+0+DOC+XML+V0//EN&language=EN (accessed June 8, 2016).
5 European Commission. EC Commissioner Andriukaitis, Statement to the European Parliament Plenary, Feb 2, 2016—Commission statement—Commission action to comply with Judgement in case T-521/14: Sweden vs the Commission. https://ec.europa.eu/commission/2014-2019/andriukaitis/announcements/ep-plenary-commission-statement-commission-action-comply-judgement-case-t-52114-sweden-vs-commission_en (accessed June 2, 2016).
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7 UNEP/WHO. State of the science of endocrine disrupting chemicals, 2013, World Health Organization, United Nation Environmental Program, Geneva http://www.who.int/ceh/publications/endocrine/en/index.html (accessed June 2, 2016).
8 Skinner, MK, Manikkam, M, Guerrero-Bosagna, C, Epigenetic transgenerational actions of endocrine disruptors. Reprod Toxicol 31 (2011), 337–343.
9 European Commission. Roadmap-defining criteria for identifying endocrine disruptors in the context of the implementation of the plant protection product regulation and biocidal products regulation, 2014, European Commission, Brussels http://ec.europa.eu/smart-regulation/impact/planned_ia/docs/2014_env_009_endocrine_disruptors_en.pdf (accessed June 2, 2016).
10 European Commission. Report on public consultation on defining criteria for identifying endocrine disruptors in the context of the implementation of the plant protection product regulation and biocidal products regulation, 2015, European Commission, Brussels http://ec.europa.eu/health/endocrine_disruptors/docs/2015_public_consultation_report_en.pdf (accessed June 2, 2016).
11 Endocrine-disrupting chemicals in the European Union Endocrine Society. https://www.endocrine.org/∼/media/endosociety/files/advocacy-and-outreach/position-statements/2015/position_statement_edc_eu.pdf, 2015 (accessed June 2, 2016).
12 Trasande, L, Zoeller, RT, Hass, U, et al. Estimating burden and disease costs of exposure to endocrine-disrupting chemicals in the European Union. J Clin Endocrinol Metab 100 (2015), 1245–1255.
13 BfR. German Federal Institute for Risk Assessment). Joint DE – UK position paper. Regulatory definition of an endocrine disrupter in relation to potential threat to human health. Proposal applicable in the regulatory context of Plant Protection Products, Biocidial Products, and Chemicals targeted within REACH. http://www.bfr.bund.de/cm/343/regulatory_definition_of_an_endocrine_disrupter_in_relation_to_potential_threat_to_human_health.pdf, May 16, 2011 (accessed June 5, 2016).
