Effects of various concentrations of glycolic acid at the corneoxenometry and collaxenometry bioassays.

[en] BACKGROUND: Glycolic acid is an alpha-hydroxy acid used as a chemical peeling for more than a quarter century. The primary tissue target is the stratum corneum. OBJECTIVE: This study aims to assess the effects of various concentrations of glycolic acid on the stratum corneum and collagen fibers using two selected bioassays. METHODS: Corneoxenometry was performed to test the effects on human stratum corneum. Collaxenometry was similarly designed to quantify the effect on sheets of collagen fibers. Different glycolic acid concentrations ranging from 5% to 70% in alcohol were tested, respectively, for 3- and 10-min exposure times. RESULTS: Both bioassays showed consistent reactivities with a dose-effect relationship when using a 3-min exposure time. By contrast, the tests appeared unreliable or uninformative for the 10-min exposure time. CONCLUSION: Corneoxenometry and collaxenometry appear useful for in vitro testing peeling agents during short exposure times.

Disciplines :

Dermatology

Author, co-author :

Xhauflaire, Emmanuelle ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Pierard, Claudine ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Pierard, Gérald ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Language :

English

Title :

Effects of various concentrations of glycolic acid at the corneoxenometry and collaxenometry bioassays.

Publication date :

2008

Journal title :

Journal of Cosmetic Dermatology

ISSN :

1473-2130

eISSN :

1473-2165

Publisher :

Blackwell Publishing

Volume :

Issue :

Pages :

194-8

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 16 December 2008

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Bibliography

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