Reference : The mortality associated with erythema nodosum leprosum in Ethiopia: a retrospective ...
Scientific journals : Article
Human health sciences : Public health, health care sciences & services
Human health sciences : Immunology & infectious disease
Human health sciences : Dermatology
http://hdl.handle.net/2268/253323
The mortality associated with erythema nodosum leprosum in Ethiopia: a retrospective hospital-based study
English
WALKER, S.L. []
LEBAS, Eglantine mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatologie >]
DONI, S.N. []
LOCKWOOD, D.N. []
LAMBERT, S.M. []
Mar-2014
PLoS Neglected Tropical Diseases
Public Library of Science
13
8
Yes (verified by ORBi)
International
1935-2727
1935-2735
CA
[en] Adrenal Cortex Hormones ; Erythema Nodosum ; Ethiopia ; Immunosuppressive Agents ; Leprosy, Lepromatous
[en] Background:Erythema nodosum leprosum (ENL) is a debilitating multisystem disorder which complicates leprosy. It is characterised by fever, malaise and painful erythematous cutaneous nodules. ENL is often recurrent or chronic in nature and frequently severe. Patients often require prolonged treatment with high doses of oral corticosteroids. There are no data on the mortality associated with treated ENL.Methodology:The notes of patients who were admitted, discharged, transferred to another facility or died with a diagnosis of leprosy or a leprosy-related complication for a five year period were reviewed.Result/Discussion:414 individuals were identified from the ward database. 312 (75.4%) patient records were located and reviewed. Ninety-nine individuals had ENL and 145 had a Type 1 reaction. The median age of individuals with ENLwas 25 years. Eight patients with erythema nodosum leprosum died compared with two diagnosed with Type 1 reaction. This difference is statistically significant (p = 0.0168, Fisher's Exact Test). There is a significant mortality and morbidity associated with ENL in this Ethiopian cohort. The adverse outcomes seen are largely attributable to the chronic administration of oral corticosteroids used to control the inflammatory and debilitating symptoms of the condition.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/253323
10.1371/journal.pntd.0002690

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