Article (Scientific journals)
Capillary whole-blood IgG-IgM COVID-19 selftest as a serological screening tool for SARSCoV-2 infection adapted to the general public
Tonen-Wolyec, Serge; Dupont, Raphael; Batina-Agasa, Salomon et al.
2020In PLoS ONE, p. 1-18
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Keywords :
COVID-19; SARS-CoV-2; self-test
Abstract :
[en] The practicability of a prototype capillary whole-blood IgG-IgM COVID-19 self-test (Exacto® COVID-19 self-test, Biosynex Swiss SA, Freiburg, Switzerland) as a serological screening tool for SARS-CoV-2 infection adapted to the general public was evaluated in across-sectional, general adult population study performed between April and May 2020 in Strasbourg, France, consisting of face-to-face, paper-based, semi-structured, and selfadministrated questionnaires. Practicability was defined as the correct use of the self-test and the correct interpretation of the result. The correct use of self-test was conditioned by the presence of the control band after 15-min of migration. The correct interpretation of the tests was defined by the percent agreement between the tests results read and interpret by the participants compared to the expected results coded by the numbers and verified by trained observers. A total of 167 participants (52.7% female; median age, 35.8 years; 82% with post-graduate level) were enrolled, including 83 and 84 for usability and test results interpretation substudies, respectively. All participants (100%; 95% CI: 95.6– 100) correctly used the self-test. However, 12 (14.5%; 95% CI: 8.5–23.6) asked for verbal help. The percent agreement between the tests results read and interpret by the participants compared to the expected results was 98.5% (95% CI: 96.5–99.4). However, misinterpretation occurred in only 2.3% of positive and 1.2% of invalid test results. Finally, all (100%) participants found that performing the COVID-19 self-test was easy; and 98.8% found the interpretation of the self-test results easy. Taken together, these pilot observations demonstrated for the first-time, high practicability and satisfaction of COVID-19 selftesting for serological IgG and IgM immune status, indicating its potential for use by the general public to complete the arsenal of available SARS-CoV-2 serological assays in the urgent context of the COVID-19 epidemic.
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
Tonen-Wolyec, Serge;  Ecole Doctorale Régionale D’Afrique Centrale en Infectiologie Tropicale, Franceville, Gabon ; Faculty of Medicine and Pharmacy, University of Kisangani, Kisangani, The Democratic Republic of the Congo
Dupont, Raphael;  BioSynex, Strasbourg, France
Batina-Agasa, Salomon;  Faculty of Medicine and Pharmacy, University of Kisangani, Kisangani, The Democratic Republic of the Congo
HAYETTE, Marie-Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Service de microbiologie clinique
Bélec, Laurent;  Laboratoire de Virologie, Hôpital Europeen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France ; Université Paris Descartes, Sorbonne Paris Cité, Paris, France
Language :
English
Title :
Capillary whole-blood IgG-IgM COVID-19 selftest as a serological screening tool for SARSCoV-2 infection adapted to the general public
Publication date :
15 October 2020
Journal title :
PLoS ONE
eISSN :
1932-6203
Publisher :
Public Library of Science, United States - California
Pages :
1-18
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Biosynex SA
Available on ORBi :
since 18 November 2020

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