Hybridization of short complementary PNAs to G-quadruplex forming oligonucleotides: An electrospray mass spectrometry study.

Amato, Jussara; Oliviero, Giorgia; De Pauw, Edwin; Gabelica, Valérie

doi:10.1002/bip.21124

Article (Scientific journals)

Hybridization of short complementary PNAs to G-quadruplex forming oligonucleotides: An electrospray mass spectrometry study.

Amato, Jussara; Oliviero, Giorgia; De Pauw, Edwin et al.

2009 • In Biopolymers, 91 (4), p. 244-255

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/2524

DOI
10.1002/bip.21124

PubMed
19065573

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Keywords :

mass spectrometry; DNA; PNA; noncovalent; supramolecular chemistry; G-quadruplex

Abstract :

[en] We investigated the interaction of the short PNA strand [acccca]-PNA with oligodeoxynucleotides containing one, two, or four tracts of TGGGGT units. Electrospray ionization mass spectrometry allowed exploring the wide variety of complex stoichiometries that were found to coexist in solution. In water, the PNA strand forms short heteroduplexes with the complementary DNA sequences, but higher-order structures are also found, with PNA(2n)*DNA(n) triplex units, culminating in precipitation at very low ionic strength. In the presence of ammonium acetate, there is a competition between PNA*DNA heteroduplex formation and DNA G-quadruplex formation. Heteroduplex formation is favored when the PNA + DNA mixture in ammonium acetate is heated and cooled at room temperature, but not if the PNA is added at room temperature to the pre-formed G-quadruplex. We also found that the short [acccca]-PNA strand binds to G-quadruplexes. (c) 2008 Wiley Periodicals, Inc. Biopolymers, 2008.

Research Center/Unit :

Giga-Systems Biology and Chemical Biology - ULiège

Disciplines :

Chemistry
Biochemistry, biophysics & molecular biology

Author, co-author :

Amato, Jussara; Università di Napoli Federico II, Italy > Facoltà di Scienze Biotecnologiche > Dipartimento di Chimica delle Sostanze Naturali

Oliviero, Giorgia; Università di Napoli Federico II, Italy > Facoltà di Scienze Biotecnologiche > Dipartimento di Chimica delle Sostanze Naturali

De Pauw, Edwin ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie physique, spectrométrie de masse

Gabelica, Valérie ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie physique, spectrométrie de masse

Language :

English

Title :

Hybridization of short complementary PNAs to G-quadruplex forming oligonucleotides: An electrospray mass spectrometry study.

Publication date :

2009

Journal title :

Biopolymers

ISSN :

0006-3525

eISSN :

1097-0282

Publisher :

Wiley Interscience, New York, United States - New York

Volume :

Issue :

Pages :

244-255

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www3.interscience.wiley.com

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique

Commentary :

This is the pre-peer reviewed version of the following article: Amato J, Oliviero G, De Pauw E, Gabelica V., Hybridization of short complementary PNAs to G-quadruplex forming oligonucleotides: An electrospray mass spectrometry study. Biopolymers. Published ahead of print on Dec. 8, 2008.

Available on ORBi :

since 16 December 2008

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