Reference : Nouvelles strategies dans la prise en charge de l'allo-immunisation foeto-maternelle ...
Scientific journals : Article
Human health sciences : Reproductive medicine (gynecology, andrology, obstetrics)
Nouvelles strategies dans la prise en charge de l'allo-immunisation foeto-maternelle anti-RHD (Rhesus)
[en] New Approaches to Prenatal Diagnosis of Rhesus Incompatibility
Minon, J. M. [> > > >]
Gerard, Christiane mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie biologique et immuno hématologie >]
Dricot, J. F. [> > > >]
Neve, C. [ > > ]
Senterre, J. M. [ > > ]
Schaaps, Jean-Pierre mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Embryologie >]
Foidart, Jean-Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >]
Revue Médicale de Liège
Hopital de Baviere
Yes (verified by ORBi)
[en] fetal hemolytic disease ; Prenatal diagnosis ; Fetal RHD genotype ; Fetal Doppler
[en] Despite generalisation of anti-D immunoprophylaxis, RhD allo-immunisation still remains the major cause of severe haemolytic disease of the fetus and of the newborn (HDFN). The routine follow up of pregnant women comprises: the ABO/D, Rh/Kell red cells typing and the search for irregular antibodies. In case of anti-D immunisation, the paternal Rh phenotype, when known, provides useful information regarding the probability for the fetus to have inherited the D antigen and thereby to be exposed to the risk of HDFN. The antibody titre, which is predictive of possible in vivo haemolysis, must be interpreted in the light of the previous obstetric history, and can lead to the decision of invasive amniocentesis. Then the measurement of the optical density (deltaOD450 nm) and the fetal RhD typing can be realised on amniotic fluid. New molecular techniques make it possible now to demonstrate the presence of fetal DNA in maternal plasma. These methods lying on non invasive procedures could advantageously be applied to the genotyping of fetal RHD during pregnancy. The present paper aims to discuss the predictive values of RHD fetal genotype in maternal plasma of RhD negative mothers. The ante-partum management of immunised pregnant women is reviewed in the light of this new molecular approach combined to Doppler ultrasonography of the fetal middle cerebral artery. This non invasive method for determining fetal RHD genotype could be systematically proposed to all RhD negative pregnant women for a better targeted prenatal follow-up and an increased efficacy of RhD prophylaxis.

File(s) associated to this reference

Fulltext file(s):

Open access
Minon JM 2006.pdfPublisher postprint703.11 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.