95% confidence interval, (95% CI); Blood; CKD-EPI equation based on creatinine and cystatin c combined, (eGFRcr-cys); CKD-EPI equation based on cystatin c, (eGFRcys); CKD-EPI equation based on serum creatinine, (eGFRcr); Case-control study; Fanconi syndrome; Hereditary fructose intolerance; Kidney; Vessels; alanine, (Ala); aldolase B, (ALDOB); arginine, (Arg); asparagine, (Asn); carotid-femoral pulse wave velocity, (cf-PWV); chronic kidney disease epidemiology collaboration, (CKD-EPI); citrulline, (Cit); cysteine, (Cys); difference, (Δ); estimated glomerular filtration rate, (eGFR); glucokinase regulatory protein, (GKRP); glutamic acid, (Glu); glutamine, (Gln); glycine, (Gly); hereditary fructose intolerance, (HFI); histidine, (His); intrahepatic triglyceride, (IHTG); isoleucine, (Ile); laser doppler flowmetry, (LDF); leucine, (Leu); lysine, (Lys); methionine, (Met); ornithine, (Orn); perfusion units, (PU); phenylalanine, (Phe); proline, (Pro); ratio of tubular maximum reabsorption of phosphate to GFR, (TmP/GFR); reactive hyperemia index, (RHI); reactive hyperemia peripheral arterial tonometry, (RH-PAT); serine, (Ser); soluble E-selectin, (sE-selectin); statistical package of social sciences, (SPSS); taurine, (Tau); threonine, (Thr); tryptophan, (Try); tubular reabsorption of phosphate, (TRP); tyrosine, (Tyr); valine, (Val); von willebrand factor, (vWF)
Abstract :
[en] Objective: Previous studies have shown that patients with hereditary fructose intolerance (HFI) are characterized by a greater intrahepatic triglyceride content, despite a fructose-restricted diet. The present study aimed to examine the long-term consequences of HFI on other aldolase-B-expressing organs, i.e. the kidney and vascular endothelium. Methods: Fifteen adult HFI patients were compared to healthy control individuals matched for age, sex and body mass index. Aortic stiffness was assessed by carotid-femoral pulse wave velocity (cf-PWV) and endothelial function by peripheral arterial tonometry, skin laser doppler flowmetry and the endothelial function biomarkers soluble E-selectin [sE-selectin] and von Willebrand factor. Serum creatinine and cystatin C were measured to estimate the glomerular filtration rate (eGFR). Urinary glucose and amino acid excretion and the ratio of tubular maximum reabsorption of phosphate to GFR (TmP/GFR) were determined as measures of proximal tubular function. Results: Median systolic blood pressure was significantly higher in HFI patients (127 versus 122 mmHg, p = .045). Pulse pressure and cf-PWV did not differ between the groups (p = .37 and p = .49, respectively). Of all endothelial function markers, only sE-selectin was significantly higher in HFI patients (p = .004). eGFR was significantly higher in HFI patients than healthy controls (119 versus 104 ml/min/1.73m(2), p = .001, respectively). All measurements of proximal tubular function did not differ significantly between the groups. Conclusions: Adult HFI patients treated with a fructose-restricted diet are characterized by a higher sE-selectin level and slightly higher systolic blood pressure, which in time could contribute to a greater cardiovascular risk. The exact cause and, hence, clinical consequences of the higher eGFR in HFI patients, deserves further study.
Disciplines :
Genetics & genetic processes
Author, co-author :
Simons, Nynke
Debray, François-Guillaume ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Maladies métaboliques d'origine génétique
Schaper, Nicolaas C.
Feskens, Edith J. M.
Hollak, Carla E. M.
Bons, Judith A. P.
Bierau, Jörgen
Houben, Alfons J. H. M.
Schalkwijk, Casper G.
Stehouwer, Coen D. A.
Cassiman, David
Brouwers, Martijn C. G. J.
Language :
English
Title :
Kidney and vascular function in adult patients with hereditary fructose intolerance.
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