eating disorders; genetic correlation; substance use
Abstract :
[en] Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [r(g) ], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (r(g) = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (r(g) = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (r(g) = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (r(gs) = -0.19 to -0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors.
Disciplines :
Genetics & genetic processes
Author, co-author :
Munn-Chernoff, Melissa A.
Johnson, Emma C.
Chou, Yi-Ling
Coleman, Jonathan R. I.
Thornton, Laura M.
Walters, Raymond K.
Yilmaz, Zeynep
Baker, Jessica H.
Hübel, Christopher
Gordon, Scott
Medland, Sarah E.
Watson, Hunna J.
Gaspar, Héléna A.
Bryois, Julien
Hinney, Anke
Leppä, Virpi M.
Mattheisen, Manuel
Ripke, Stephan
Yao, Shuyang
Giusti-Rodríguez, Paola
Hanscombe, Ken B.
Adan, Roger A. H.
Alfredsson, Lars
Ando, Tetsuya
Andreassen, Ole A.
Berrettini, Wade H.
Boehm, Ilka
Boni, Claudette
Boraska Perica, Vesna
Buehren, Katharina
Burghardt, Roland
Cassina, Matteo
Cichon, Sven
Clementi, Maurizio
Cone, Roger D.
Courtet, Philippe
Crow, Scott
Crowley, James J.
Danner, Unna N.
Davis, Oliver S. P.
de Zwaan, Martina
Dedoussis, George
Degortes, Daniela
DeSocio, Janiece E.
Dick, Danielle M.
Dikeos, Dimitris
Dina, Christian
Dmitrzak-Weglarz, Monika
DOCAMPO MARTINEZ, Elisa ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de rhumatologie
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