Poster (Scientific congresses and symposiums)
Higher Insulin Resistance In Female ICU Patients
Uyttendaele, Vincent; Knopp, Jennifer L.; Shaw, Geoffrey M. et al.
2020e-ISICEM - International Symposium on Intensive Care & Emergency Medicine
 

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Keywords :
Glycemic control; Insulin resistance; Intensive Care; Sex difference; Insulin sensitivity; Hyperglycemia
Abstract :
[en] Introduction: Sex differences in the metabolic response to critical illness are unknown. This retrospective analysis examines potential differences in the evolution of insulin sensitivity (SI) and its variability (%ΔSI) between sexes. Significant differences would suggest differences in the metabolic stress response and glycaemic response to insulin therapy, and, thus, the need for more personalised glycaemic control (GC). Methods: Retrospective data from 145 ICU patients (N=8710 hours) are used to hourly identify hourly model-based SI and its rate of change %ΔSI in 6-hour blocks from ICU admission to 72 hours. The evolution of SI and %ΔSI are compared for males and females. Hypothesis testing (95% confidence interval (CI) bootstrapped difference in medians) assesses if differences are significant, and equivalence testing assesses if differences are clinically equivalent. Results: Females have significantly lower SI levels than males (p<0.05), and this difference is not clinically equivalent (Figure 1; top). Differences in %ΔSI are not significant (p>0.05), and these differences are clinically equivalent (Figure 1; bottom). Conclusion: Given significantly lower SI levels, but equivalent variability, for women, equally safe and effective GC should be achievable for both sexes. However, women may require more insulin to achieve these goals. GC protocol designs should thus account for these differences in the future.
Disciplines :
Endocrinology, metabolism & nutrition
Engineering, computing & technology: Multidisciplinary, general & others
Anesthesia & intensive care
Author, co-author :
Uyttendaele, Vincent ;  Université de Liège - ULiège > In silico-Model-based therapeutics, Critical Care Basic Sc.
Knopp, Jennifer L.
Shaw, Geoffrey M.
Desaive, Thomas  ;  Université de Liège - ULiège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles
Chase, J. Geoffrey
Language :
English
Title :
Higher Insulin Resistance In Female ICU Patients
Publication date :
2020
Event name :
e-ISICEM - International Symposium on Intensive Care & Emergency Medicine
Event date :
15-18 Septembre 2020
Audience :
International
Available on ORBi :
since 01 October 2020

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