Article (Scientific journals)
Reduced protein availability by albumen removal during chicken embryogenesis decreases body weight and induces hormonal changes.
Willems, Els; Wang, Yufeng; Koppenol, Astrid et al.
2015In Experimental Physiology, 100 (11), p. 1298-308
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Keywords :
Albumins/administration & dosage/deficiency; Animal Nutritional Physiological Phenomena; Animals; Body Weight; Chick Embryo; Chickens; Corticosterone/blood; Embryonic Development; Female; Liver/physiology; Male; Ovum; Thyroxine/blood; Triiodothyronine/blood
Abstract :
[en] What is the central question of this study? Prenatal protein undernutrition by albumen removal in an avian model of fetal programming leads to long-term programming effects, but when do these effects first appear and are these programming effects regulated by the same candidate genes as in mammals? What is the main finding and its importance? The present results indicate that prenatal protein undernutrition by albumen removal induces phenotypical and hormonal changes in the early posthatch period, when the mismatch between the prenatal and postnatal environment first arises, but these changes are not accompanied by an altered gene expression of the selected candidate genes. Studies of the chicken offer a unique model for investigation of the direct effects of reduced prenatal protein availability by the partial replacement of albumen with saline in eggs at embryonic day 1 (albumen-deprived group). The results were compared with mock-treated sham chicks and non-treated control chicks. Although no differences in hatch weight were found, body weight and growth were reduced in the albumen-deprived chicks until 3 weeks of age. The feed intake of the albumen-deprived chicks, however, was increased compared with the control (day 13-21) and the sham chicks (day 16-18). In the albumen-deprived chicks, the ratio of thyroxine to 3,5,3'-triiodothyronine in the plasma was increased compared with the control chicks, whereas the plasma corticosterone level was increased only at day 7 compared with both other groups. The plasma glucose concentration and glucose tolerance were not affected by treatment. Several candidate genes previously associated with effects of prenatal protein deprivation in mammals were examined in the liver of newly hatched chicks. Gene expression of glycogen synthase 2, glycogen phosphorylase 1, peroxisome proliferator-activated receptor α and γ and glucocorticoid receptor was not affected by the treatment. In conclusion, reduction of prenatal protein availability led to differences in body weight and influenced hormones involved in metabolism and growth. Gene expression of the selected candidate genes was not altered, in contrast to mammals.
Disciplines :
Animal production & animal husbandry
Author, co-author :
Willems, Els
Wang, Yufeng
Koppenol, Astrid
Lesuisse, Jens
Franssens, Lies
Decuypere, Eddy
Buyse, Johan
Everaert, Nadia ;  Université de Liège - ULiège > Département GxABT > Ingénierie des productions animales et nutrition
Language :
English
Title :
Reduced protein availability by albumen removal during chicken embryogenesis decreases body weight and induces hormonal changes.
Publication date :
2015
Journal title :
Experimental Physiology
ISSN :
0958-0670
eISSN :
1469-445X
Publisher :
Blackwell, Oxford, United Kingdom
Volume :
100
Issue :
11
Pages :
1298-308
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
© 2015 The Authors. Experimental Physiology © 2015 The Physiological Society.
Available on ORBi :
since 22 September 2020

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