Characterization of CD79αcy + cells in placentas from ruminants

[en] Previous work carried out to characterise different immune cells in ruminant placentas found strong CD79αcy nuclear labelling in cells histologically resembling trophoblast cells. In the attempt to characterize this cell population, placentomes collected from cattle, sheep and water buffaloes were examined by immunohistochemistry with single and double labelling using monoclonal antibodies (mAb) against B lymphocytes and trophoblast cells. Most CD79αcy + cells co-expressed placental lactogen or cytokeratin and were CD21 and MHC class II negative strongly suggesting they do not have a B cell origin. However, a potential immunological role of these cells cannot be ruled out and it is currently unknown if the findings described may have an impact on physiological knowledge, health, and or diseases pathogenesis in ruminants. © 2019 Elsevier B.V.

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Cantón, G. J.; Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, EH26 0PZ, United Kingdom, Instituto Nacional de Tecnología Agropecuaria (INTA), EEA BalcarceB7620EMA, Argentina

Schock, A.; Animal and Plant Health Agency (APHA) Lasswade, Pentlands Science Park, Bush Loan, Penicuik, EH26 0PZ, United Kingdom

Melo de Sousa, Noelita ; Université de Liège - ULg

Beckers, Jean-François ; Université de Liège - ULiège > Département des sciences fonctionnelles (DSF) > Département des sciences fonctionnelles (DSF)

Chianini, F.; Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, EH26 0PZ, United Kingdom

Language :

English

Title :

Characterization of CD79αcy + cells in placentas from ruminants

Publication date :

2019

Journal title :

Veterinary Immunology and Immunopathology

ISSN :

0165-2427

eISSN :

1873-2534

Publisher :

Elsevier, Amsterdam, Netherlands

Volume :

217

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

Rural and Environment Science and Analytical Services Division, RESASInstituto Nacional de TecnologÃa Agropecuaria, INTARural and Environment Science and Analytical Services Division, RESAS

Available on ORBi :

since 12 September 2020

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Bibliography

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