Le médicament du mois. Ertugliflozine seule et en combinaisons fixes : «la passe de trois» pour ce nouvel inhibiteur des SGLT2.

Scheen, André

Article (Scientific journals)

Scheen, André

2020 • In Revue Médicale de Liège, 75 (9), p. 626-632

Peer reviewed

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https://hdl.handle.net/2268/250835

PubMed
32909416

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Keywords :

Ertugliflozin; Metformin; SGLT2 inhibitor; Sitagliptin; VERTIS; 4 inhibitor; DPP; Type 2 diabetes

Abstract :

[en] Ertugliflozin is a new sodium-glucose cotransporter type 2 inhibitor (SGLT2i) that is indicated in the treatment of type 2 diabetes. It has been investigated in the large phase 3 development programme VERTIS, in monotherapy and in association with different antidiabetic medications, including insulin. The add-on of ertugliflozin to metformin (VERTIS MET) and the association ertugliflozin-sitagliptin (VERTIS-SITA, VERTIS FACTORIAL, VERTIS SITA2) showed a significant reduction in glycated haemoglobin, without hypoglycaemia, together with a diminution of body weight and arterial blood pressure. As expected, more genital mycotic infections were observed, the only adverse event consistently reported. The cardiovascular safety of ertugliflozin has been demonstrated in VERTIS CV. Ertugliflozin is commercialized with two doses 5 mg and 15 mg. This SGLT2i is also available in fixed-dose combinations, ertugliflozin-metformin and ertugliflozin-sitagliptin. The three presentations offer a greater flexibility to the practitioner to optimize therapeutic choices for a complex disease where the treatment should be individualized according to the patient profile.

Disciplines :

Pharmacy, pharmacology & toxicology
Endocrinology, metabolism & nutrition

Author, co-author :

Scheen, André ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques

Language :

French

Title :

Le médicament du mois. Ertugliflozine seule et en combinaisons fixes : «la passe de trois» pour ce nouvel inhibiteur des SGLT2.

Alternative titles :

[en] Ertugliflozin alone and in fixed-dose combinations : «pass of three»

Publication date :

2020

Journal title :

Revue Médicale de Liège

ISSN :

0370-629X

eISSN :

2566-1566

Publisher :

Université de Liège. Revue Médicale de Liège, Liège, Belgium

Volume :

Issue :

Pages :

626-632

Peer reviewed :

Peer reviewed

Available on ORBi :

since 11 September 2020

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123 (4 by ULiège)

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Bibliography

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