Protection cardiorénale avec les inhibiteurs des SGLT2 : d’EMPA-REG OUTCOME à VERTIS CV.

Scheen, André

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Article (Scientific journals)

Protection cardiorénale avec les inhibiteurs des SGLT2 : d’EMPA-REG OUTCOME à VERTIS CV.

Scheen, André

2020 • In Revue Médicale Suisse, 16 (703), p. 1483-1488

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https://hdl.handle.net/2268/250436

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32852168

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Keywords :

type 2 diabetes; empagliflozin; EMPA-REG OUTCOME

Abstract :

[en] The landmark study EMPA-REG OUTCOME firstly demonstrated both a cardiovascular and renal protection with empagliflozin in patients with type 2 diabetes (T2DM) and established cardiovascular disease. Since 2015, two other trials showed a reduction in the hospitalisations for heart failure and the progression of the renal disease, also in patients with multiple risk factors, CANVAS with canagliflozin and DECLARE-TIMI 58 with dapagliflozin. CREDENCE (canagliflozin in T2DM patients with kidney disease) confirmed a renal protection and DAPA-HF (dapagliflozin in patients, with or without T2DM, but reduced ejection fraction) showed a less acute deterioration of heart failure. The positive effect of SGLT2 inhibitors on heart failure predominates, an effect recently confirmed in VERTIS CV with ertugliflozin.

Disciplines :

Pharmacy, pharmacology & toxicology
Endocrinology, metabolism & nutrition

Author, co-author :

Scheen, André ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques

Language :

French

Title :

Protection cardiorénale avec les inhibiteurs des SGLT2 : d’EMPA-REG OUTCOME à VERTIS CV.

Alternative titles :

[en] Cardiovascular and renal protection with SGLT2 inhibitors: from EMPA-REG OUTCOME to VERTIS CV

Publication date :

2020

Journal title :

Revue Médicale Suisse

ISSN :

1660-9379

Publisher :

Medecine et Hygiène, Switzerland

Volume :

Issue :

703

Pages :

1483-1488

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 31 August 2020

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Bibliography

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