Reference : Effective arterial elastance as an index of pulmonary vascular load.
Scientific journals : Article
Human health sciences : General & internal medicine
Effective arterial elastance as an index of pulmonary vascular load.
Morimont, Philippe mailto [Université de Liège - ULiège > > Frais communs médecine >]
Lambermont, Bernard mailto [Université de Liège - ULiège > > Frais communs médecine >]
Ghuysen, Alexandre mailto [Université de Liège - ULiège > Département des sciences de la santé publique > Réanimation - Urgence extrahospitalière >]
Gerard, Pierre [Université de Liège - ULiège > > Chirurgie abdominale- endocrinienne et de transplantation >]
Kolh, Philippe mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, humaines et path. >]
Lancellotti, Patrizio mailto [Université de Liège - ULiège > > Cardiologie >]
Tchana-Sato, Vincent [Université de Liège - ULiège > > Chirurgie cardio-vasculaire >]
Desaive, Thomas mailto [Université de Liège - ULiège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles >]
D'Orio, Vincenzo mailto [Université de Liège - ULiège > Département des sciences cliniques > Médecine d'urgence - bioch. et phys. hum. normales et path. >]
American Journal of Physiology - Heart and Circulatory Physiology
American Physiological Society
Yes (verified by ORBi)
[en] The aim of this study was to test whether the simple ratio of right ventricular (RV) end-systolic pressure (Pes) to stroke volume (SV), known as the effective arterial elastance (Ea), provides a valid assessment of pulmonary arterial load in case of pulmonary embolism- or endotoxin-induced pulmonary hypertension. Ventricular pressure-volume (PV) data (obtained with conductance catheters) and invasive pulmonary arterial pressure and flow waveforms were simultaneously recorded in two groups of six pure Pietran pigs, submitted either to pulmonary embolism (group A) or endotoxic shock (group B). Measurements were obtained at baseline and each 30 min after injection of autologous blood clots (0.3 g/kg) in the superior vena cava in group A and after endotoxin infusion in group B. Two methods of calculation of pulmonary arterial load were compared. On one hand, Ea provided by using three-element windkessel model (WK) of the pulmonary arterial system [Ea(WK)] was referred to as standard computation. On the other hand, similar to the systemic circulation, Ea was assessed as the ratio of RV Pes to SV [Ea(PV) = Pes/SV]. In both groups, although the correlation between Ea(PV) and Ea(WK) was excellent over a broad range of altered conditions, Ea(PV) systematically overestimated Ea(WK). This offset disappeared when left atrial pressure (Pla) was incorporated into Ea [Ea * (PV) = (Pes - Pla)/SV]. Thus Ea * (PV), defined as the ratio of RV Pes minus Pla to SV, provides a convenient, useful, and simple method to assess the pulmonary arterial load and its impact on the RV function.
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