Sarcopenia and health-related outcomes: an umbrella review of observational studies

[en] Background: The clinical relevance of sarcopenia has increasingly been recognized. However, whether it is associated with the development of other medical conditions is still unclear. Therefore, we aimed to capture the scale of outcomes that have been associated with the presence of sarcopenia and systematically assess the quality, strength, and credibility of these associations using an umbrella review methodology. Methods: A systematic review in several databases was carried out, until 20th February 2019. For each association, random-effects summary effect size, 95% confidence intervals (CIs), heterogeneity (I 2), evidence for small-study effect, evidence for excess significance bias, and 95%-prediction intervals were estimated. We used these metrics to categorize the evidence of significant outcomes (p < 0.05) from class I (convincing) to class IV (weak), according to pre-established criteria. Results: From 358 abstracts, 6 meta-analyses with 14 associations were included. Sarcopenia was associated with higher risk of other comorbidities and mortality in 11 of 14 outcomes explored. However, only 3 outcomes (i.e., association between sarcopenia and increased risk of death in community-dwelling older people [odds ratio, OR = 3.60; 95% CI 2.96–4.37; n = 14,305], disability [OR = 3.04; 95% CI 1.80–5.12; n = 8569], and falls [OR = 1.60; 95% CI 1.31–1.97; n = 12,261]) presented a highly suggestive evidence (class II). Other association was classified as having only a weak evidence. Conclusion: Sarcopenia is associated with several adverse health-related outcomes in older people, and its associations with mortality, disability, and falls are supported by a highly suggestive evidence. The effect of interventions on sarcopenia to improve these outcomes needs to be investigated. © 2019, © 2019, European Geriatric Medicine Society.

Disciplines :

Public health, health care sciences & services

Author, co-author :

Veronese, N.; National Research Council, Neuroscience Institute, Aging Branch Via Giustiniani, 2, Padua, Italy

Demurtas, J.; Primary Care Department Azienda, USL Toscana Sud Est, Grosseto, Italy

Soysal, P.; Department of Geriatric Medicine, Bezmialem Vakif University, Istanbul, Turkey

Smith, L.; The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, United Kingdom

Torbahn, G.; Institute for Biomedicine of Aging, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nuremberg, Germany

Schoene, D.; Institute of Medical Physics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

Schwingshackl, L.; Institute for Evidence in Medicine (for Cochrane Germany Foundation), Medical Center, University of Freiburg, Freiburg, Germany

Sieber, C.; Institute for Biomedicine of Aging, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nuremberg, Germany, Kantonsspital Winterthur, Winterthur, Switzerland

Bauer, J.; Center for Geriatric Medicine, University of Heidelberg, Agaplesion Bethanien Hospital, Heidelberg, Germany

Cesari, M.; Geriatric Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy

More authors (8 more)

Language :

English

Title :

Sarcopenia and health-related outcomes: an umbrella review of observational studies

Publication date :

2019

Journal title :

European Geriatric Medicine

ISSN :

1878-7649

eISSN :

1878-7657

Publisher :

Springer International Publishing

Volume :

Issue :

Pages :

853-862

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 13 August 2020

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