Article (Scientific journals)
Influence of mesoporous silica on powder flow and electrostatic properties on short and long term
Lumay, Geoffroy; Pillitteri, Salvatore; Marck, Michaël et al.
2019In Journal of Drug Delivery Science and Technology, 53
Peer reviewed
 

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Abstract :
[en] We study the effect of three types of mesoporous silica (MPS) particles on the flow of three common excipients: microcrystalline cellulose, lactose and maize starch. While MPS are commonly considered as excipient and also as drug delivery carrier, the effects of MPS as flow aid additive and as powder stabilizer are investigated. MPS particles, called additive in the present study, are found to decrease powder cohesiveness, in particular for powders having higher water content and higher initial cohesiveness. According to both particle and pore size of MPS particles, the effect can be immediate (for small MPS particles having small pore size) or on the longer term (for larger MPS particles having higher pore size). Moreover, the electrostatic properties of the blends are modified by the presence of MPS. The quantity of electrostatic charge created in the blends during a flow in contact with stainless steel is decreased by the addition of MPS. We show that this decrease is induced by a modification of electric resistivity. © 2019 Elsevier B.V.
Disciplines :
Physics
Author, co-author :
Lumay, Geoffroy ;  Université de Liège - ULiège > Département de physique > Physique expér. de la matière molle et des syst. complexes
Pillitteri, Salvatore ;  Université de Liège - ULiège > Département de physique > Physique statistique
Marck, Michaël ;  Université de Liège - ULiège > Département de physique > Physique statistique
Monsuur, F.;  W. R. Grace & Co, Worms, Germany
Pauly, T.;  W. R. Grace & Co, Worms, Germany
Ribeyre, Q.;  GranuTools, Awans, Belgium
Francqui, F.;  GranuTools, Awans, Belgium
Vandewalle, Nicolas  ;  Université de Liège - ULiège > Département de physique > Physique statistique
Language :
English
Title :
Influence of mesoporous silica on powder flow and electrostatic properties on short and long term
Publication date :
2019
Journal title :
Journal of Drug Delivery Science and Technology
ISSN :
1773-2247
Publisher :
Editions de Sante
Volume :
53
Peer reviewed :
Peer reviewed
Funders :
Axis IT and T
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since 07 August 2020

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