Article (Scientific journals)
Testosterone effects on functional amygdala lateralization: A study in adolescent transgender boys and cisgender boys and girls
Beking, T.; Burke, S. M.; Geuze, R. H. et al.
2020In Psychoneuroendocrinology, 111
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Keywords :
Amygdala; Asymmetry; Gender dysphoria; Lateralization; Testosterone; Transgender
Abstract :
[en] The influence of testosterone on the development of human brain lateralization has been subject of debate for a long time, partly because studies investigating this are necessarily mostly correlational. In the present study we used a quasi-experimental approach by assessing functional brain lateralization in trans boys (female sex assigned at birth, diagnosed with Gender Dysphoria, n = 21) before and after testosterone treatment, and compared these results to the functional lateralization of age-matched control groups of cisgender boys (n = 20) and girls (n = 21) around 16 years of age. The lateralization index of the amygdala was determined with functional magnetic resonance imaging (fMRI) during an emotional face matching task with angry and fearful faces, as the literature indicates that boys show more activation in the right amygdala than girls during the perception of emotional faces. As expected, the lateralization index in trans boys shifted towards the right amygdala after testosterone treatment, and the cumulative dose of testosterone treatment correlated significantly with amygdala lateralization after treatment. However, we did not find any significant group differences in lateralization and endogenous testosterone concentrations predicted rightward amygdala lateralization only in the cis boys, but not in cis girls or trans boys. These inconsistencies may be due to sex differences in sensitivity to testosterone or its metabolites, which would be a worthwhile course for future studies. © 2019 The Authors
Disciplines :
Neurosciences & behavior
Author, co-author :
Beking, T.;  University of Groningen, Department Clinical & Developmental Neuropsychology, Grote Kruisstraat 2/1, Groningen, TS 9712, Netherlands
Burke, S. M.;  Leiden University, Brain & Development Research Centre, Department of Developmental and Educational Psychology, Wassenaarseweg 52, Leiden, AK 2333, Netherlands
Geuze, R. H.;  University of Groningen, Department Clinical & Developmental Neuropsychology, Grote Kruisstraat 2/1, Groningen, TS 9712, Netherlands
Staphorsius, A. S.;  Amsterdam University Medical Centers, Location VU, Department of Internal Medicine, Center of Expertise on Gender Dysphoria, PO Box 7057, Amsterdam, MB 1007, Netherlands
Bakker, Julie  ;  Université de Liège - ULiège > Neurosciences-Neuroendocrinology
Groothuis, A. G. G.;  University of Groningen, Groningen Institute for Evolutionary Life Sciences, Nijenborgh 7, Groningen, AG 9747, Netherlands
Kreukels, B. P. C.;  Amsterdam University Medical Centers, Location VU, Department of Medical Psychology, Center of Expertise on Gender Dysphoria, PO Box 7057, Amsterdam, MB 1007, Netherlands
Language :
English
Title :
Testosterone effects on functional amygdala lateralization: A study in adolescent transgender boys and cisgender boys and girls
Publication date :
2020
Journal title :
Psychoneuroendocrinology
ISSN :
0306-4530
eISSN :
1873-3360
Publisher :
Elsevier Ltd
Volume :
111
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
NWO - Nederlandse Organisatie voor Wetenschappelijk Onderzoek [NL]
Available on ORBi :
since 06 August 2020

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