[en] E. multilocularis is a small tapeworm which uses different species of foxes and rodents as final and intermediate hosts respectively. In humans, infection with the metacestode stage can result in a potentially lethal liver condition named alveolar echinococcosis (AE). Recent studies in central Europe have show that E. multilocularis has a wider geographic range than previously anticipated. By the end of the 1980s, endemic areas of E. multilocularis were know to exist in only four countries, but now the parasite is present in at least 14 European countries. This paper provide recent data on the biology of E. multilocularis, the epidemiology of AE and the different tools which are available to treat or prevent this disease which seems in apparent extension.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Hanosset, Régis
Mignon, Bernard ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Parasitologie et pathologie des maladies parasitaires
Losson, Bertrand ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Parasitologie et pathologie des maladies parasitaires
Language :
French
Title :
Recent data on a current zoonosis: alveolar echinococcosis due to Echinococcus multilocularis
AHLMANN V. Zum vorkommen von Echinococcus multilocularis im Saarland. In Tackmann K., Janitschke K. (Eds.), Zur epidemiologischen Situation des Echinococcus multilocularis breitet sich eine gefährliche parasitose in der Bundesrepublik Deutschland aus ? RKI-Hefte 14, Robert-Koch Institut, Berlin, 1997, 51-69.
ALTINTAS N. Past to present: echinococcosis in Turkey. Acta Trop., 85, 105-112.
AMMANN R.W., ILITSCH N., MARINCEK B., FREIBURGHAUS A.U. Effect of chemotherapy on the larval mass and long-term course of alveolar echinococcosis. Hepatology, 1994, 19, 735-742.
AMMANN R.W., FLEINER-HOFFMANN A., GRIMM F., ECKERT J. Long-term mebendazole therapy may be parasitocidal in alveolar echinococcosis. J. Hepatol., 1998, 29, 994-998.
AUBERT M., JACQUIER P., ARTOIS M., BARRAT M.J., BASILE A.M. Le portage d'Echinococcus multilocularis par le renard (Vulpes vulpes) en Lorraine. Conséquences sur la contamination humaine. Rec. Med. Vet., 1987, 163, 839-843.
AYDIN Y., BARLAS O., YOLA C., AYDIN I.H., CEVIZ A., ALADAG A., ÖREN D., AKDEMIR D. Alveolar hydatid disease of the brain: report of four cases. J. Neurosurg., 1986, 65, 115-119.
BACCIARINI L.N., GOTTSTEIN B., PAGAN O., REHMANN P., GRÖNE A. Hepatic alveolar echinococcis in cynomolgus monkeys (Macaca fascicularis). Vet Pathol., 2004, 41, 229-232.
BALLEK D., TAKLA M., ISING VOLLMER S., STOYE M. Zur Helminthenfauna des Rotfuchses (Vulpes vulpes Linné 1758) in Nordhessen und ostwestalen. Teil 1: Zestoden. Dtsch. Tierärztl. Woschenschr., 1992, 99, 353-392
BAUER C. Anthelmintika zum Einsatz gegen helminthen des verdauungtrukes, de Atemwege und Harnblase bei Hund und Katze, eine übersicht. Kleintierpraxis, 1994, 39, 771-790.
BAUMEISTER S., POHLMEYER K., KUSCHFELDT S., STOYE M. Prevalence of Echinococcus multilocularis and other metacestodes and cestodes in the muskrat (Ondatra zibethicus Link 1795) in Lower Saxony. Dtsch. Tierarztl. Wochenschr., 1997, 104, 448-452.
BERKE O. Choropleth mapping of regional count data of Echinococcus multilocularis among red foxes in Lower Saxony, Germany. Prev. Vet. Med., 2001, 52, 119-31.
BESSONOV A.S. Echinococcus multilocularis infection in Russia and neighbouring countries prevalence. Helminthologia., 1998, 35, 73-78.
BOISSIEU J.J., MORAND M. Note relative à l'échinococcose du renard dans le Jura. Bull. Sci. Vet. Med. Comp., 1981, 83, 259-262.
BOUSSINESQ M., BRESSON S., LIANCE M., HOUIN R. A new natural intermediate host of Echinococcus multilocularis in France: The muskrat (Ondatra zibethicus L). Ann. Parasitol. Hum. Comp., 1986, 61, 431-434.
BRACK M., TACKMANN K., CONRATHS F. J., RENSING S. Alveolar hydatidosis (Echinococcus multilocularis) in a captive rhesus monkey (Macaca mulatta) in Germany. Trop. Med. Int. Health, 1997, 2, 754-759.
BRESSON-HADNI S., KOCH S., BEURTON I., VUITTON D.A., BARTHOLOMOT B., HRUSOVSKY S., HEYD B., LENYS D., MINELLO A., BECKER M.C., VANLEMMENS C., MANTION G.A., MIGUET J.F. Primary disease recurrence after liver transplantation for alveolar echinococcosis: long-term evaluation in 15 patients. Hepatology, 1999, 30, 857-863.
BRETAGNE S., GUILLOU J.P., MORAND M., HOUIN R. Détection des œufs d'Echinococcus multilocularis Leuckart, 1863 dans les fèces de renard (Vulpes vulpes, Linnaeus, 1758) par amplification en chaîne par polymérase. Rev. Sci. Tech. Off. Int. Epiz., 1992, 11, 1051-1056.
BRETAGNE S., GUILLOU J.P., MORAND M., HOUIN R. Detection of Echinococcus multilocularis DNA in fox faeces using amplification. Parasitology, 1993, 106, 193-199.
BROCHIER B., COPPENS P., LOSSON B., AUBERT M.F.A., BAUDUIN B., BARRAT M.J., COSTY F., PEHARPRE D., POUPLARD L., PASTORET P.P. Enquête sur l'infestation du renard roux (Vulpes vulpes) par Echinococcus multilocularis en province du Luxembourg (Belgique). Ann. Med. Vet., 1992, 136, 497-501.
BROCHIER B., BAUDUIN B., CHALON P., PASTORET P.P. Estimation de l'abondance du renard roux (Vulpes vulpes, L.) en Ardenne belge par relevé des mortalités, comptages nocturnes et recensement des terriers de mise bas. Cah. Ethol., 1999, 19, 57-74.
BROTEL G. Helminthoses intestinales du renard roux (Vulpes vulpes L.) à propos de 110 autopsies dans l'Isère. Contribution à l'étude épidémiologique de l'échinococcose alvéolaire. (Thèse médecine vétérinaire) : Toulouse, 1989, 165 p.
CLAUDON M., BRACARD S., PLENAT F., REGENT D., BERNADAC P., PICARD L. Spinal involvement in alveolar echinococcosis: assessment of two cases. Radiology, 1987, 162, 571-572.
DEBLOCK S., PÉTAVY A.F., GILOT B. Helminthes intestinaux du renard commun (Vulpes vulpes L.) dans le Massif Central. Deuxième note concernant le Cantal. Can. J. Zool., 1988, 66, 1562-1569.
DELBECQUE K., DETRY O., HAYETTE M.P., JEUKENS T., DELVENNE P., HARDY N., DELWAIDE J., DEMONTY J., BOVERIE J., DEMOL P., HAUWAERT C., HONORÉ P., BONIVER J., JACQUET N. A case of hepatic alveolar echinococcosis contracted in Belgium. Acta Gastro-Ent. Belg., 2002, 65, 55-60.
DELATTRE P., DAMANGE J.P., PASCAL M., HABERT M. Rôle de la prédation et influence de la structure du paysage agraire sur le développement des cycles d'abondance d'Arvicola terrestris Scherman. EPPO bulletin, 1988, 18, 415-422.
DEPLAZES P., GOTTSTEIN B. A monoclonal antibody against Echinococcus multilocularis Em2 antigen. Parasitology, 1991, 103, 41-49.
DEPLAZES P., ECKERT J. Diagnosis of the Echinococcus multilocularis infection in final hosts. Appl. Parasitol., 1996, 37, 245-252.
DEPLAZES P., ARNOLD P., KASER-HOTZ B., GARDELLE O., GUSCETTI F., HALLER M., ECKERT J. Concurrent infection of the liver and the intestine with Echinococcus multilocularis in dogs. Arch. Int. Hidatid., 1997, 32, 201-202.
DEPLAZES P., ECKERT J. Veterinary aspects of alveolar echinococcosis : a zoonosis of public health significance. Vet. Parasitol., 2001, 98, 65-87.
DEPLAZES P., DINKEL A., MATHIS A. Molecular tools for studies on the transmission biology of Echinococcus multilocularis. Parasitology, 2003, 127, S53-S61.
DEPLAZES P., HEGGLIN D., GLOOR S.,ROMIG T. Wilderness in the city : urbanization of Echinococcus multilocularis. Trends Parasitol., 2004, 20, 77-84.
DINKEL A., VON NICKISCH-ROSENEGK M., BILGER B., MERLI M., LUCIUS R., ROMIG T. Detection of Echinococcus multilocularis in the definitive host: coprodiagnosis by PCR as an alternative to necropsy. J. Clin. Microbiol., 1998, 36, 1871-1876.
DUBINSKY P., SVOBODOVA V., TURCEKOVA L., LITERAK I., MARTINEK K., REITEROVA K., KOLAROVA L., KLIMES J., MRLIK V. Echinococcus multilocularis in Slovak Republic: the first record in the red foxes (Vulpes vulpes). Helminthologia, 1999, 36, 105-110.
DUBINSKY P., VARADY M., REITEROVA K., MITERPAKOVA M., TURCEKOVA L. Prevalence of Echinococcus multilocularis in red foxes in Slovak Republic. Helminthologia, 2001, 38, 215-219.
ECKERT J. The "dangerous fox taperworm" (Echinococcus multilocularis) and human alveolar echinococcosis in central Europe. Berl. Munch. Tierarztl., 1996, 109, 202-210.
ECKERT J., CONRATHS F.J., TACKMANN K., Echinococcosis: an emerging or re-emerging zoonosis?. Int. J. Parasitol., 2000, 30, 1283-1294.
ECKERT J., DEPLAZES P. Immunological and molecular techniques for diagnosing the Echinococcus multilocularis infection in definitive and intermediate hosts. Acta parasitol., 2001, 46, 1-7.
ECKERT J., GEMMELL M.A., MESLIN F.X., PAWLOWSKI Z.S. WHO/OIE Manual on echinococcosis in humans and animals: a public health problem of global concern. Office International des Epizooties and World Health Organization, Paris, 2001a, 265 p.
ECKERT J., THOMPSON R.C.A., BUCKLAR H., BILGER B., DEPLAZES P. Prüfung der Wirkung von Epsiprantel (Cestex®) gegen Echinococcus multilocularis bei Hunden und Katzen. Berl. Münch. Tierärztl. Wochenschr., 2001b, 114, 121-126.
ECKERT J. Predictive values and quality control of techniques for the diagnosis of Echinococcus multilocularis in definitive hosts. Acta Trop., 2003, 85, 1-7.
ECKERT J., DEPLAZES P. Biological, epidemiological, and clinical aspects of echinococcosis, a zoonosis of increasing concern. Clin. Microbiol. Rev., 2004, 17, 107-135.
EMRE A., OZDEN I., BILGE O., ARICI C., ALPER A., OKTEN A., ACUNAS B., ROZANES I., ACARLI K., TEKAR Y., ARIOGUL O. Alveolar echinococcosis in Turkey. Experience from an endemic region. Dig. Surg., 2003, 20, 301-305.
ENGE A. Ergebnisse der Untersuchungen von fuchsen auf Echinococcus multilocularis im Freistaat Sachsen im Zeitraum 1990 bis 1995. In Tackmann K., Janitschke K. (Eds.), Zur epidemiologischen Situation des Echinococcus multilocularis breitet sich eine gefährliche parasitose in der Bundesrepublik Deutschland aus ? RKI-Hefte 14, Robert-Koch Institut, Berlin, 1996, 111-113.
EWALD D. Prägvalenz von Echinococcus multilocularis bei Rotfüchsen (Vulpes vulpes L.) in der Nord-, Ost- und Südschweiz sowie im Fürstentum Liechtenstein (Dissertation Phil.). University of Zurich : 1993, 110p.
FAUSER S., KERN P. T-Lymphocyte cytokine mRNA expression in cystic echinococcosis. Acta Trop., 1997, 64, 35-51.
GOTTSTEIN B., FELLEISEN R. Protective immune mechanism against the metacestode of Echinococcus multilocularis. Parasitology Today., 1995, 11, 320-326.
GOTTSTEIN B., SAUCY F., DEPLAZES P., REICHEN J., DEMIERRE G., BUSATO A., ZUERCHER C., PUGIN P. Is high prevalence of Echinococcus multilocularis in wild and domestic animals associated with disease incidence in humans? Emerg. Infect. Dis.,, 2001, 7, 408-412.
GOTTSTEIN B., DAI W.J., WALKER M., STETTLER M., MULLER N., HEMPHILL A. An intact laminated layer is important for the establishment of secondary Echinococcus multilocularis infection. Parasitol. Res., 2002, 88, 822-828.
GUERRET S., VUITTON D A., LIANCE M., PATER C., CARBILLET J.P. Echinococcus multilocularis: relationship between susceptibility/resistance of experimental mice and liver fibrogenesis. Parasitol. Res., 1998, 84, 657-667.
HALLER M., DEPLAZES P., GUSCETTI F., SARDINAS J.C., REICHLER I., ECKERT J. Surgical and chemotherapeutic treatment of alveolar echinococcosis in a dog. J. Am. Anim. Hosp. Assoc., 1998, 34, 309-314.
HANOSSET R., MIGNON B., LOSSON B. Echinococcus multilocularis in southern Belgium: spatial distribution of carriage by the red fox (Vulpes vulpes) and results in the musk rat (Ondatra zibethicus), a potentially important intermediate host. In: World Association for the Advancement of Veterinary Parasitology. Kathleen Story Harrington : New Orleans, 2003.
HEGGLIN D., WARD P., DEPLAZES P. Anthelmintic baiting of foxes against urban contamination with Echinococcus multilocularis. Emerg Infect Dis., 2003, 9, 1266-1272.
HOFER S., GLOOR S., MULLER U., MATHIS A., HEGGLIN D., DEPLAZES P. High prevalence of Echinococcus multilocularis in urban red foxes (Vulpes vulpes) and voles (Arvicola terrestris) in the city of Zürich, Switzerland. Parasitology, 2000, 120, 135-142.
HOLCMAN B., HEATH D.D. The early stages of Echinococcus granulosus development. Acta Trop., 1997, 64, 5-17.
HOUIN R., DENIAU M., LIANCE M., PUEL F. Arvicola terrestris an intermediate host of Echinococcus multilocularis in France: epidemiological consequences. Int. J. Parasitol., 1982, 12, 593-600.
ITO A., OKAMOTO M., KARIWA H., ISHIGURO T., HASHIMOTO A., NAKAO M. Antibody responses against Echinococcus multilocularis antigens in naturally infected Rattus norvegicus. J. Helminthol., 1996, 70, 355-357.
ITO A., SAKO Y., YAMASAKI H., MAMUTI W., NAKAYA K., NAKAO M., ISHIKAWA Y. Development of EM18-immunoblot and EM18-Elisa for specific diagnosis of alveolar echinococcosis. Acta Trop., 2003a, 85, 1-10.
ITO A., URBANI C., JIAMIN Q., VUITTON D A., DONGCHUAN Q., HEATH D D., CRAIG P S., ZHENG F., SCHANTZ P M. Control of echinococcosis and cysticercosis: a public health challenge to international cooperation in China., Acta Trop., 2003b, 86, 3-17.
ITO A., ROMIG T., TAKAHASHI K., Perspective on control options for Echinococcus multilocularis with particular reference to Japan. Parasitology, 2003c, 127, S159-172.
JANOVSKY M., BACCIARINI L., SAGER H., GRONE A., GOTTSTEIN B. Echinococcus multilocularis in a European beaver from Switzerland. J. Wildl. Dis., 2002, 38, 618-20.
JENKINS D.J. Does the presence of Spirometra erinacei reduce the efficacity of praziquantel against Echinococcus granulosus in dogs? Int. J. Parasitol., 1998, 28, 1943-1944.
JENKINS D.J., ROMIG T. Efficacy of Droncit® spot-on (praziquantel) 4 % w/v against immature and mature Echinococcus multilocularis in cats. Int. J. Parasitol., 2000, 30, 959-962.
JONAS D., DRÄGER K. Untersuchungen von Füchsen auf Echinococcus multilocularis: Entwicklung seit 1982 und Situation 1996/97 in Rheinland-Pfalz. Tierärztl. Umsch., 1998, 53, 214-221.
JUNG H., HURTADO M., TULIO MEDINA M., SANCHEZ M., SOTELO J. Dexamethasone increase plasma levels of albendazole. J. Neurol., 1990, 237, 279-280.
KAJI Y., TANIYAMA H., MATSUKAWA K., OKADA H., TSUNODA S., TAGAMI M., AKITA H. First incidence of multilocularis echinococcosis in a race horse in Japan. J. Vet. Med. Sci., 1993, 55, 869-870.
KAMIYA M., OOI H.K., OKU Y., OKAMOTO M., OHBAYASHI M., SEKI N. Isolation of Echinococcus multilocularis from the liver of swine in Hokkaido, Japan. Jpn. J. Vet. Res., 1987, 35, 99-107.
KANAZAWA T., ASAHI H., HATA H., MOCHIDA K., KAGEI N., STADECKER M.J. Arginine-dependent generation of reactive nitrogen intermediate is instrumental in the in vitro killing of protoscolex of Echinococcus multilocularis by activated macrophages. Parasite Immunol., 1993, 15, 619-623.
KAPEL C.M.O., SAEED I. Echinococcus multilocularis - a new zoonotic parasite in Danemark. Dansk. veterinaertidsskrift., 2000, 83, 14-16.
KERN P, AMMON A, KRON M, SINN G, SANDER S, PETERSEN LR, GAUS W, KERN P. Risk factors for alveolar echinococcosis in humans Emerg Infect Dis., 2004, 10, 2088-93.
KIMURA H., FURUYA K., KAWASE S., SATO C., TAKAHASHI K., URAGUCHI K., ITO T. YAGI K. Epidemiology of alveolar echinococcosis in Hokkaido, Japan. Arch. Int. Hidatid., 1999, 33, 85-89.
KIUPEL H. Zur epidemiologischen situation des Echinococcus multilocularis in Mecklenburg-Vorpommern. In Tackmann K., Janitschke K. (Eds.), Zur epidemiologischen Situation des Echinococcus multilocularis breitet sich eine gefährliche parasitose in der Bundesrepublik Deutschland aus ? RKI-Hefte 14, Robert-Koch Institut, Berlin, 1996, 123.
KONDO H., WADA Y., BANDO G., KOSUGE M., YAGI K., OKU Y. Alveolar hydatidosis in a gorilla and a ring-tailed lemur in Japan. J. Vet. Med. Sci., 1996, 58, 447-449.
LANGE H., EGGER R., BIRCHER J. Increase systemic availability of albendazole when taken with a fatty meal. Eur. J. Clin. Pharmacol., 1988, 34, 315-317.
LEIBY P.D., CARNEY W.P., WOODS C.E. Studies on sylvatic echinococcosis. III. Host occurrence and geographic distribution of Echinococcus multilocularis in the north central United States. J. Parasitol., 1970, 56, 1141-1150.
LEIBY P.D., KRITZKY D.C. Echinococcus multilocularis a possible domestic life cycle in central north America and its public health implication. J. Parasitol., 1972, 58, 1213-1215.
LIANCE M. Les échinococcoses : aspects épidé miologiques, physio-pathologiques et immunologiques. Ann. Instit. Pasteur, 1999, 10, 113-120.
LIN Y., HONG L. The biology and geographical distribution of Echinococcus multilocularis in China. Endemic Dis. Bull., 1991, 6, 117-125.
LIU Y.H. Continuous or intermittent treatment with albendazole?. Arch. Int. Hidatid., 1997, 32, 171-173.
LOSSON B., COIGNOUL F. Larval Echinococcus multilocularis infection in a dog. Vet. Rec., 1997, 141, 49-50.
LOSSON B., MIGNON B., BROCHIER B., BAUDUIN B., PASTORET P.P. Infestation du renard roux (Vulpes vulpes) par Echinococcus multilocularis dans la province du Luxembourg (Belgique) : résultats de l'enquête effectuée entre 1993 et 1995. Ann. Med. Vet., 1997, 141, 149-153.
LOSSON B., KERVYN T., DETRY J., PASTORET P.P., MIGNON B., BROCHIER B. Echinococcus multilocularis in the red fox (Vulpes vulpes) in southern Belgium: a prevalence study. Vet. Parasitol., 2003, 117, 23-28.
MALCZEWSKI A., ROCKI B., RAMISZ A., ECKERT J. Echinococcus multilocularis (Cestoda), the causative agent of alveolar echinococcosis in humans: First record in Poland. J. Parasitol., 1995, 81, 321-324.
MALCZEWSKI A., RAMISZ A., ROCKI B., BIENKO R., BALICKA-RAMISZ A., ECKERT J. Echinococcus multilocularis in red foxes (Vulpes vulpes) in Poland: an update of the epidemiological situation. Acta Parasitol., 1999, 44, 68-72.
MANFRAS B J., REUTER S., WENDLAND T., BOEHM B O., KERN P. Impeded Th1 CD4 memory T cell generation in chronic-persisting liver infection with Echinococcus multilocularis. Int. Immunol., 2004, 16, 43-50.
MANFREDI M.T., GENCHI C., DEPLAZES P., TREVISIOL K., FRAQUELLI C. Echinococcus multilocularis in red foxes in Italy. Vet. Rec., 2002, 15, 757.
MARTINEK K., KOLAROVA L., HAPL E., LITERAK I. Echinococcus multilocularis in European wolves (Canis lupus). Parasitol. Res., 2001, 87, 838-839.
MATHIS A., DEPLAZES P., ECKERT J. Improved test system for PCR-based specific detection of Echinococcus multilocularis eggs. J. Helminthol., 1996, 70, 219-222.
MIYAUCHI T., SAKUI M., ISHIGE M., FUKUMOTO S.I., UEDA A., ITO M., OHBAYASHI M. Acase of multilocular echinococcosis in a horse. Jpn. J. Vet. Res., 1984, 32, 171-173.
MONNIER P., CLIQUET F., AUBERT M., BRETAGNE S. Improvement of a polymerase chain reaction assay for the detection of Echinococcus multilocularis DNA in faecal samples of foxes. Vet. Parasitol., 1996, 67, 185-195.
NEBEL W. Die Ergebnisse bisheriger untersuchungen auf Echinococcus multilocularis in Schleswig-Holstein. In Tackmann K., Janitschke K. (Eds.), Zur epidemiologischen Situation des Echinococcus multilocularis breitet sich eine gefährliche parasitose in der Bundesrepublik Deutschland aus ? RKI-Hefte 14, Robert-Koch Institut, Berlin, 1996, 97.
NONAKA N., IIDIA M., YAGI K., ITO T., OOI H K., OKU Y., KAMIYA M. The course of coproantigen excretion in Echinococcus multilocularis infections in foxes and an alternative definitive host, golden hamster. Int. J. Parasitol, 1996, 26, 1271-1278.
NONAKA N., TSUKADA H., ABE N., OKU Y., KAMIYA M. Monitoring of Echinococcus multilocularis infection in red foxes in Shiretoko, Japan, by coproantigen detection. Parasitology, 1998, 117, 193-200.
NOTHDURFT H.D., JELINEK T., MAI A., SIGL B., VON SONNENBURG F., LÖSCHER T. Epidemiology of alveolar echinococcosis in Southern Germany (Bavaria). Infection, 1995, 23, 85-88.
OAKLEY G A. Anthelmintics for cats and dogs. Anpar books : England, 1991, 447 p.
OHBAYASHI M. Parasitology. In : Uchino J., Sato N (Eds.), Alveolar Echinococcosis in Liver. Hokkaido University School of Medicine : Sapporo, 1993, 21-32.
OKAMOTO M., FUJITA 0., ARIKAWA J., KUROSAWA T., OKU Y., KAMIYA M. Natural Echinococcus multilocularis infection in a Norway rat, Rattus norvegicus, in southern Hokkaido, Japan. Int. J. Parasitol., 1992, 22, 681-684.
PAVLASEK I. Actual situation in the occurrence of Echinococcus multilocularis in the red foxes in Europe and in the Czech Republic [in Czech]. Remedia Klin. Mikrobiol., 1998, 2, 233-240.
PESSON B., FERRY R., DESSET M.C., PETAVY A.F., VOLTZ A. Les parasites intestinaux du renard en Alsace (communication affichée), congrès Société Française de Parasitologie, Rennes 1985.
PETAVY A.F., DEBLOCK S., PROST C. Epidémiologie de l'échinococcose alvéolaire en France. I. - helminthes intestinaux du renard commun (Vulpes vulpes L.) en Haute-Savoie. Ann. Parasitol. Hum. Comp., 1990, 65, 22-27.
PETAVY A.F., TENORA F., DEBLOCK S., SERGENT V. Echinococcus multilocularis in domestic cats in France a potential risk factor for alveolar hydatid disease contamination in humans. Vet. Parasitol., 2000, 87, 151-156.
PFEIFFER F. Zum vorkommen von Echinococcus multilocularis beim Rotfuchs im südlichen Sachsen-Anhalt. Beiträge jagd-u. Wildforschung, 1997, 22, 215-217.
PFISTER T., SCHAD V., SCHELLING U., LUCIUS R., FRANK W. Incomplete development of larval Echinococcus multilocularis (Cestoda: Taeniidae) in spontaneously infected wild boars. Parasitol. Res., 1993, 79, 617-618.
RAOUL F., DEPLAZES P., NONAKA N., PIARROUX R., VUITTON D.A., GIRAUDOUX P. Assessment of the epidemiological status of Echinococcus multilocularis in foxes in France using ELISA coprotests on fox faeces collected in the field. Int. J. Parasitol., 2001, 31, 1579-1588.
RAUSCH R.L., SCHILLER E. L. Studies on the helminth fauna of Alaska. XX. The histogenesis of the alveolar larva of Echinococcus species. J. Infect. Dis., 1954, 94, 178-186.
RAUSCH R.L., WILSON F., SCHANTZ P.M. A program to reduce the risk of infection by Echinococcus multilocularis : the use of praziquantel to control the cestode in a village in the hyperendemic region of Alaska. Ann. Trop. Med. Parasitol., 1990, 84, 239-250.
REHMANN P., GRONE A., LAWRENZ A., PAGAN O., GOTTSTEIN B., BACCIARINI L.N. Echinococcus multilocularis in two lowland gorillas (Gorilla g. gorilla). J. comp. Pathol., 2003, 129, 85-88.
REUTER S., JENSEN B., BUTTENSCHOEN K., KRATZER W., KERN P. Benzimidazoles in the treatment of alveolar echinococcosis: a comparative study and review of the literature. J. Antimicrob. Chemother., 2000, 46, 451-456.
RICHARDS K.S., MORRIS D.L., TAYLOR D.H. Echinococcus multilocularis: ultrastructural effect of in vivo albendazole and praziquantel therapy, singly and in combination. Ann. Trop. Med. Parasitol., 1989, 83, 479-484.
RIETSCHEL W., KIMMIG P. Alveolar echinococcosis in a cynomolgus monkey. Tierarztl. Prax., 1994, 22, 85-88.
ROSSELOT P. Contribution à l'étude épidé miologique de l'échinococcose alvéolaire dans les départements de Haute-Savoie et du Rhône. (Thèse de pharmacie). Lyon, 1985, 105 p.
SAILER M., SOELDER B., ALLEBERGER F., ZAKNUM D., FEICHINGER H., GOTTSTEIN B. Alveolar echinococcosis of the liver in a six-year-old girl with acquired immuno-deficiency syndrome. J. Pediatr., 1997, 130, 320-323.
SAKAI H., NONAKA N., YAGI K., OKU Y., KAMIYA M. Coproantigen detection in a routine fox survey of Echinococcus multilocularis infection in Hokkaido, Japan. Parasitol. Int., 1998, 47, 47-51.
SAKUI M., ISHIGE M., FUKUMOTO S., UEADA A., OHBAYASHI M. Spontaneous Echinococcus multilocularis infection in Swine in North-Eastern Hokkaido, Japan. Jpn. J. Parasitol., 1984, 10, 291-296.
SARCIRON M.E., WALCHSHOFER N., WALBAUM S., ARSAC C., DESCOTES J., PETAVY A.F., PARIS J. Increases in the effects of Albendazole on Echinococcus multilocularis metacestodes by the dipeptide methyl ester (PHE-PHE-OME). Am. J. Trop. Med. Hyg., 1997, 56, 226-230.
SCHANTZ P.M., CHAI J., CRAIG P.S., ECKERT J., JENKINS D.J., MACPHERSON C.N.L., THAKUR A. Epidemiology and control of hydatidose disease. In : Thompson R.C.A., lymbery A.J. (Eds.), Echinococcus and hydatid disease. CAB International : Wallingford, 1995, 233-331.
SCHELLING U., FRANK W., WILL R., ROMIG T., LUCIUS R. Chemotherapy with praziquantel has the potential to reduce the prevalence of Echinococcus multilocularis in wild foxes (Vulpes vulpes). Ann. Trop. Med. Parasitol., 1997, 91, 179-186.
SRETER T., SZELL Z., EGYED Z., VARGA I. Echinococcus multilocularis : an emerging pathogen in Hungary and central eastern Europe? Emerg. Infec. Dis., 2003, 9, 384-386.
STEHR GREEN J.K., STEHR GREEN P.A., SCHANTZ P.M., WILSON J.F., LANIER A. Risk factors for infection with Echinococcus multilocularis in Alaska. Am. J. Trop. Med. Hyg., 1988, 38, 380-385.
STELLNBERGER K., PECHAN P. Zum vorkommen des fuchsbandwarmes Echinococcus multilocularis in Oberösterreich. Vet. J., 1996, 48, 12.
STIEGER C., HEGGLIN D., SCHWARZENBACH S., MATHIS A., DEPLAZES P. Spatial and temporal aspect of urban transmission of Echinococcus multilocularis. Parasitology, 2002, 124, 631-640.
STORANDT S.T., KAZACOS K.R. Echinococcus multilocularis identified in Indiana, Ohio and East Illinois. J. Parasitol., 1993, 79, 305-307.
STORANDT S.T., VIRCHOW D.R., DRYDEN M.W., HYGNSTROM S.E ., KAZACOS K.R. Distribution and prevalence of Echinococcus multilocularis in wild predators in Nebraska, Kansas, and Wyoming. J. Parasitol., 2002, 88, 422-25.
TACKMANN K., LÖSCHNER U., MIX H., STAUBACH C., THULKE H.H., CONRATHS F.J. Spatial distribution patterns of Echinococcus multilocularis (Leuckart 1863) (Cestoda: Cyclophyllidea : Taeniidae) among red foxes in an endemic focus in Brandenburg, Germany. Epidemiol. Infect., 1998, 120, 101-109.
TACKMANN K., LÖSCHNER U., MIX H., STAUBACH C., THULKE H.H., ZILLER. M., CONRATHS F.J. A field study to control Echinococcus multilocularis infections of the red fox (Vulpes vulpes) in an endemic focus. Epidemiol. Infect., 2001, 127, 577-587.
TAKLA M. Merkblatt zur aktuellen Information über die Desundheitsgefahrdung des Menschen durch den kleine fuchsbandwarm Echinococcus multilocularis. In Tackmann K., Janitschke K. (Eds.), Zur epidemiologischen Situation des Echinococcus multilocularis breitet sich eine gefährliche parasitose in der Bundesrepublik Deutschland aus ? Robert-Koch Institut, Berlin, 1996, 78-90.
TAYLOR D.H., MORRIS D.L., RICHARDS K.S., REFFIN D. Echinococcus multilocularis: in vivo results of therapy with albendazole and praziquantel. Trans. R. Soc. Trop. Med. Hyg., 1988, 82, 611-615.
TAYLOR D.H., MORRIS D.L., RICHARDS K.S., REFFIN D. Comparison of albendazole, mebendazole and praziquantel chemotherapy of Echinococcus multilocularis in a gerbil model. Gut, 1989, 30, 1401-1405.
THOMAS H., GÖNNERT R. The efficacy of praziquantel against cestodes in cats, dogs and sheep. Res. Vet. Sci., 1978, 24, 20-25.
THOMPSON R.C.A., LYMBERY A.J., CONSTANTINE C.C. Variation in Echinococcus : Towards a taxonomic revision of the genus. Adv. Parasitol., 1995, 35, 145-176.
TOPSAKAL C., AYDIN Y., AYDIN F., SAHIN Y., BILGE T., KASAROGLU D., DELIBALTA N. Cerebral alveolar hydatidosis : case report. Surg. Neurol., 1996, 45, 575-581.
TORGERSON P.R., PILKINGSTON J., GULLAND F.M.D., GEMMELL M.A. Further evidence for the long distance dispersal of taeniid eggs. Int. J. Parasitol., 1995, 25, 265-267.
TSUKADA H., MORISHIMA Y., NONAKA N., OKU Y., KAMIYA M. Preliminary study of the role of red foxes in Echinococcus multilocularis transmission in the urban area of Sapporo, Japon. Parasitology., 2000, 120, 423-428.
TUZUN M., ALTINORS N., ARDA S.A., HEKIMOGLU B. Cerebral hydatid disease CT and MR findings. J. Clin. Imaging, 2002, 26, 353-357.
URREA-PARIS M.A., MORENO M.J., CASADO N., RODRIGUEZ-CAABEIRO F. Echinococcus granulosus: praziquantel treatment against the metacestode stage. Parasitol. Res., 1999, 85, 999-1006.
VAN DER GIESSEN J.W.B., ROMBOUT Y.B., FRANCHIMONT J.H., LIMPER L.P., HOMAN W.L. Detection of Echinococcus multilocularis in foxes in the Netherlands. Vet. Parasitol., 1999, 82, 49-57.
VEIT P., BILGER B., SCHAD V., SCHÄFER J., FRANK W., LUCIUS R. Influence of environmental factors on the infectivity of Echinococcus multilocularis eggs. Parasitology, 1995, 110, 79-86.
VENKATESAN P. Albendazole. J. Antimicrob. Chemoth., 1998, 41, 145-147.
VERVAEKE M., DORNY P., VERCAMMEN F., GEERTS S., BRANDT J., VAN DEN BERGHE K., VERHAGEN R. Echinococcus multilocularis (Cestoda Taeniidae) in Red foxes (Vulpes vulpes) in northern Belgium. Vet. Parasitol., 2003, 115, 257-263.
VOGEL H. Echinococcus multiocularis in South Germany : I. the tapeworm stage of strains from humans and animals. Zeitschr.Tropenmed. Parasitol., 1957, 8, 404-54.
VUITTON D.A. The ambiguous role of immunity in echinococcosis: protection of the host or of the parasite? Acta trop., 2003, 85, 119-132.
VUITTON D. A., ZHOU H., BRESSON-HADNI S., WANG Q., PIARROUX M., RAOUL F., GIRAUDOUX P. Epidemiology of alveolar echinococcosis with particular reference to China and Europe. Parasitology, 2003, 127, 87-107.
WELLINGHAUSEN N., GEBERT P., KERN P. Interleukin IL-4, IL-10 and IL-12 profile in serum of patients with alveolar echinococcosis. Acta Trop., 1999, 73, 165-174.
WEN H., MAIRDAN M., JIANHUA W., YUNHAI W., JIUHUI Z., NEW R. R. C., CRAIG P. S. Efficacy of liposomal Albendazole for the treatement of E. multilocularis in rats. In : Yao M. Y. (Eds), International Archives of the Hydatidosis XXXI. Shangai Gu Ji Publishing House : Shanghai, 1993, 438-439.
WESSBECHER H., DALCHOW W., STOYE M. Zur helminthenfauna des rotfuchses (Vulpes vulpes Linné 1758) im Regierungsbezirk karlsruhe. Teil 1: Zestoden. Dtsch. Tierärztl. Woschenschr. 1994, 101, 301-340.
WORBES H., SCHACHT K.H., ECKERT J. Echinococcus multilocularis in a swamp beaver (Myocastor coypus). Angew. Parasitol., 1989, 30, 161-165.
WORBES H., HOFFMANN L. Epidemiologische Untersuchungen zum vorkommen von Echinococcus multilocularis in Thüringen. In : Tackmann K., Janitschke K. (Eds.), Zur epidemiologischen Situation des Echinococcus multilocularis breitet sich eine gefährliche parasitose in der Bundesrepublik Deutschland aus ? Robert-Koch Institut, Berlin, 1996, 98-110.
YAGI K., ITO T., ISHIGE M. A survival strategy of Echinococcus multilocularis presumed by experimental studies. In : Uchino J., Sato N. (Eds.), Alveolar Echinococcosis : Strategy for Eradication of Alveolar Echinococcosis of the Liver. Fuji Shoin : Sapporo, 1996, 97-99.
ZARIFFARD M R. Observation on Echinococcus multilocularis in Iran. Arch. Int. Hidatid., 1997, 32, 243.
