[en] A paternally expressed QTL for muscle growth and backfat thickness (BFT) has previously been identified near the IGF2 locus on the distal tip of pig chromosome 2 (SSC2p) in three experimental F2 populations. Recently, a mutation in a regulatory element of the IGF2 gene was identified as the quantitative trait nucleotide (QTN) underlying the major QTL effect on muscle growth and BFT in crosses between Large White and Wild Boar or Pietrain. This study demonstrates that the IGF2 mutation also controls the paternally expressed QTL for backfat thickness in a cross between Meishan and European Whites. In addition, a comparison of QTL of backfat thickness measured by Hennessy grading probe (HGP) and by ultrasound measurement (USM) was made. In the USM analyses, the IFG2 mutation explains the entire QTL effect on SSC2p, whereas in the HGP analysis the presence of a second minor QTL can not be excluded. Finally, this study shows that this particular IGF2 mutation does not cause the paternally expressed QTL for teat number mapping to the same region of SSC2p as the BFT QTL.
Disciplines :
Genetics & genetic processes
Author, co-author :
Jungerius, Bart J.
Van Laere, Anne-Sophie ; Université de Liège > Département de morphologie et pathologie (DMP) > Pathologie spéciale et autopsies
Te Pas, Marinus F. W.
van Oost, Bernard A.
Andersson, Leif
Groenen, Martien A. M.
Language :
English
Title :
The IGF2-intron3-G3072A substitution explains a major imprinted QTL effect on backfat thickness in a Meishan x European white pig intercross.
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Bibliography
Bidanel, J. P. & Rothschild, M. (2002). Current status of quantitative trait locus mapping in pigs. Pig News and Information 23, 39N-54N.
de Koning, D. J., Janss, L. L., Rattink, A. P., van Oers, P. A., de Vries, B. J., Groenen, M. A., van der Poel, J. J., de Groot, P. N., Brascamp, E. W. & van Arendonk, J. A. (1999). Detection of quantitative trait loci for backfat thickness and intramuscular fat content in pigs (Sus scrofa). Genetics 152, 1679-1690.
de Koning, D. J., Rattink, A. P., Harlizius, B., van Arendonk, J. A., Brascamp, E. W. & Groenen, M. A. (2000). Genome-wide scan for body composition in pigs reveals important role of imprinting. Proceedings of the National Academy of Sciences of the USA 97 7947-7950.
Haley, C. S., Knott, S. A. & Elsen, J. M. (1994). Mapping quantitative trait loci in crosses between outbred lines using least squares. Genetics 136, 1195-1207.
Hirooka, H., de Koning, D. J., Harlizius, B., van Arendonk, J. A. M., Rattink, A. P., Groenen, M. A. M., Brascamp, E. W. & Bovenhuis, H. (2001). A whole-genome scan for quantitative trait loci affecting teat number in pigs. Journal of Animal Science 79, 2320-2326.
Janss, L. L., van Arendonk, J. A. & Brascamp, E. W. (1997a . Bayesian statistical analyses for presence of single genes affecting meat quality traits in a crossed pig population. Genetics 145 395-408.
Janss, L. L., van Arendonk, J. A. & Brascamp, E. W. (1997b . Segregation analyses for presence of major genes affecting growth, backfat, and litter size in Dutch Meishan crossbreds. Journal of Animal Science 75, 2864-2876.
Jeon, J. T., Carlborg, O., Tornsten, A., Giuffra, E., Amarger, V., Chardon, P., Andersson-Eklund, L., Andersson, K., Hansson, I., Lundstrom, K. & Andersson, L. (1999). A paternally expressed QTL affecting skeletal and cardiac muscle mass in pigs maps to the IGF2 locus. Nature Genetics 21, 157-158.
Knott, S. A., Marklund, L., Haley, C. S., Andersson, K., Davies, W., Ellegren, H., Fredholm, M., Hansson, I., Hoyheim, B., Lundstrom, K., Moller, M. & Andersson, L. (1998). Multiple marker mapping of quantitative trait loci in a cross between outbred wild boar and large white pigs. Genetics 149, 1069-1080.
Lander, E. & Kruglyak, L. (1995). Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genetics 11, 241-247.
Nezer, C., Moreau, L., Brouwers, B., Coppieters, W., Detilleux, J., Hanset, R., Karim, L., Kvasz, A., Leroy, P. & Georges, M. (1999). An imprinted QTL with major effect on muscle mass and fat deposition maps to the IGF2 locus in pigs. Nature Genetics 21 155-156.
Rattink, A. P., De Koning, D. J., Faivre, M., Harlizius, B., van Arendonk, J. A. & Groenen, M.A. (2000). Fine mapping and imprinting analysis for fatness trait QTLs in pigs. Mammalian Genome 11, 656-661.
Sobel, E. & Lange, K. (1996). Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics. American Journal of Human Genetics 58 1323-1337.
Van Laere, A. S., Nguyen, M., Braunschweig, M., Nezer, C., Collette, C., Moreau, L., Archibald, A. L., Haley, C. S., Buys, N., Tally, M., Andersson, G., Georges, M. & Andersson, L. (2003). A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig. Nature 425, 832-836.
Similar publications
Sorry the service is unavailable at the moment. Please try again later.
This website uses cookies to improve user experience. Read more
Save & Close
Accept all
Decline all
Show detailsHide details
Cookie declaration
About cookies
Strictly necessary
Performance
Strictly necessary cookies allow core website functionality such as user login and account management. The website cannot be used properly without strictly necessary cookies.
This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.
Performance cookies are used to see how visitors use the website, eg. analytics cookies. Those cookies cannot be used to directly identify a certain visitor.
Used to store the attribution information, the referrer initially used to visit the website
Cookies are small text files that are placed on your computer by websites that you visit. Websites use cookies to help users navigate efficiently and perform certain functions. Cookies that are required for the website to operate properly are allowed to be set without your permission. All other cookies need to be approved before they can be set in the browser.
You can change your consent to cookie usage at any time on our Privacy Policy page.