Reference : Comorbidity of sickle cell trait and albinism: a cross-sectional survey in the Democr...
Scientific journals : Article
Human health sciences : Hematology
Comorbidity of sickle cell trait and albinism: a cross-sectional survey in the Democratic Republic of the Congo.
Kambale-Kombi, Paul [> >]
Marini Djang'Eing'A, Roland mailto [> >]
Alworong'a Opara, Jean-Pierre [> >]
Wa Inena, Gaylor Inena [> >]
Falay Sadiki, Daddy [> >]
BOEMER, François mailto [Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire Biochimie Génétique >]
BOURS, Vincent mailto [Centre Hospitalier Universitaire de Liège - CHU > Unilab > Service de génétique >]
Tshilumba, Charles Kayembe [> >]
Batina-Agasa, Salomon [> >]
Pan African Medical Journal
African Field Epidemiology Network
Yes (verified by ORBi)
[en] Comorbidity ; Democratic Republic of the Congo ; albinism ; sickle cell trait
[en] INTRODUCTION: Sickle Cell Disease (SCD) and albinism are both recessive hereditary diseases in human kind with a high prevalence in sub-Saharan Africa. This study aimed to determinate the prevalence of sickle cell trait in people living with albinism (PLA). METHODS: a cross-sectional descriptive survey was conducted in PLA attending the "Hôpital du Cinquantenaire de Kisangani". In total, by non-probabilistic convenience sampling, 82 albinos and 139 non-albinos and without any antecedents of albinism in their family were included, selected from students in the Faculty of Medicine and Pharmacy at the University of Kisangani. Blood samples were collected on "dried blood spot" and analyzed by mass spectrometry at CHU of Liège. Data were entered into an Excel file and analysed on SPSS 20.0 (Chicago, IL). RESULTS: forty-six of the 82 albinos (56.1%) were female and 43.9% male with a sex ratio of 1.28. Among albinos, 18.3% had hemoglobin AS (HbAS) and 81.7% hemoglobin AA (HbAA) compared to 18% of subjects with hemoglobin AS and 82% hemoglobin AA in the control group. The difference was not statistically significant (Chi-square=0.003, ddl=1, p=0.9544). CONCLUSION: this study highlighted that the prevalence of the sickle cell trait is high among people living with albinism, but does not differ from that observed in non-albinos in the Democratic Republic of the Congo. It is therefore important to raise awareness among this category of people about sickle cell disease and the importance of its premarital screening.
© Paul Kambale-Kombi et al.

File(s) associated to this reference

Fulltext file(s):

Open access
PAMJ-35-127.pdfPublisher postprint207.78 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.