Norine: update of the nonribosomal peptide resource

[en] Norine, the unique resource dedicated to nonribosomal peptides (NRPs), is now updated with a new pipeline to automate massive sourcing and enhance annotation. External databases are mined to extract NRPs that are not yet in Norine. To maintain a high data quality, successive filters are applied to automatically validate the NRP annotations and only validated data is inserted in the database. External databases were also used to complete annotations of NRPs already in Norine. Besides, annotation consistency inside Norine and between Norine and external sources have reported annotation errors. Some can be corrected automatically, while others need manual curation. This new approach led to the insertion of 539 new NRPs and the addition or correction of annotations of nearly all Norine entries. Two new tools to analyse the chemical structures of NRPs (rBAN) and to infer a molecular formula from the mass-to-charge ratio of an NRP (Kendrick Formula Predictor) were also integrated. Norine is freely accessible from the following URL: https://bioinfo.cristal.univ-lille.fr/norine/. © The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

Disciplines :

Life sciences: Multidisciplinary, general & others

Author, co-author :

Flissi, A.; Univ. Lille, CNRS, Centrale Lille, UMR 9189 - CRIStAL - Centre de Recherche en Informatique Signal et Automatique de Lille, Lille, F-59000, France

Ricart, E.; Proteome Informatics Group, SIB Swiss Institute of Bioinformatics, CMU, Rue Michel-Servet 1Geneva 1211, Switzerland, Computer Science Department, University of Geneva, CUI, 7 route de Drize, Carouge, 1227, Switzerland

Campart, C.; Univ. Lille, CNRS, Centrale Lille, UMR 9189 - CRIStAL - Centre de Recherche en Informatique Signal et Automatique de Lille, Lille, F-59000, France

Chevalier, M.; Univ. Lille, INRA, ISA, Univ. Artois, Univ. Littoral Côte d'Opale, Lille, F-59000, France

Dufresne, Y.; Univ. Lille, CNRS, Centrale Lille, UMR 9189 - CRIStAL - Centre de Recherche en Informatique Signal et Automatique de Lille, Lille, F-59000, France

Michalik, J.; Univ. Lille, CNRS, Centrale Lille, UMR 9189 - CRIStAL - Centre de Recherche en Informatique Signal et Automatique de Lille, Lille, F-59000, France, CNRS, cité scientifique, France

Jacques, Philippe ; Université de Liège - ULiège > Département GxABT > Microbial, food and biobased technologies

Flahaut, C.; Univ. Lille, INRA, ISA, Univ. Artois, Univ. Littoral Côte d'Opale, Lille, F-59000, France

Lisacek, F.; Proteome Informatics Group, SIB Swiss Institute of Bioinformatics, CMU, Rue Michel-Servet 1Geneva 1211, Switzerland, Computer Science Department, University of Geneva, CUI, 7 route de Drize, Carouge, 1227, Switzerland, Section of Biology, University of Geneva, Sciences III, 30 quai Ernest-AnsermetGeneva 1211, Switzerland

Leclère, V.; Univ. Lille, INRA, ISA, Univ. Artois, Univ. Littoral Côte d'Opale, Lille, F-59000, France

Pupin, M.; Univ. Lille, CNRS, Centrale Lille, UMR 9189 - CRIStAL - Centre de Recherche en Informatique Signal et Automatique de Lille, Lille, F-59000, France

Language :

English

Title :

Norine: update of the nonribosomal peptide resource

Publication date :

2020

Journal title :

Nucleic Acids Research

ISSN :

0305-1048

eISSN :

1362-4962

Publisher :

NLM (Medline)

Volume :

Issue :

Pages :

D465-D469

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 12 July 2020

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