Article (Scientific journals)
Brain Metabolism but Not Gray Matter Volume Underlies the Presence of Language Function in the Minimally Conscious State (MCS): MCS+ Versus MCS− Neuroimaging Differences
Aubinet, Charlène; Cassol, Helena; Gosseries, Olivia et al.
2020In Neurorehabilitation and Neural Repair, 34 (2), p. 172-184
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Abstract :
Background. The minimally conscious state (MCS) is subcategorized into MCS− and MCS+, depending on the absence or presence, respectively, of high-level behavioral responses such as command-following. Objective. We aim to investigate the functional and structural neuroanatomy underlying the presence of these responses in MCS− and MCS+ patients. Methods. In this cross-sectional retrospective study, chronic MCS patients were diagnosed using repeated Coma Recovery Scale–Revised assessments. Fluorodeoxyglucose-positron emission tomography data were acquired on 57 patients (16 MCS−; 41 MCS+) and magnetic resonance imaging with voxel-based morphometry analysis was performed on 66 patients (17 MCS−; 49 MCS+). Brain glucose metabolism and gray matter integrity were compared between patient groups and control groups. A metabolic functional connectivity analysis testing the hypothesis of preserved language network in MCS+ compared with MCS− was also done. Results. Patients in MCS+ presented higher metabolism mainly in the left middle temporal cortex, known to be important for semantic processing, compared with the MCS− group. The left angular gyrus was also functionally disconnected from the left prefrontal cortex in MCS− compared with MCS+ group. No significant differences were found in gray matter volume between patient groups. Conclusions. The clinical subcategorization of MCS is supported by differences in brain metabolism but not in gray matter structure, suggesting that brain function in the language network is the main support for recovery of command-following, intelligible verbalization and/or intentional communication in the MCS. Better characterizing the neural correlates of residual cognitive abilities of MCS patients contributes to reduce their misdiagnosis and to adapt therapeutic approaches. © The Author(s) 2020.
Research center :
Shinshu Public Utility Foundation for Promotion of Medical Sciences
CHU de Liège-Centre du Cerveau² - ULiège
Disciplines :
Neurosciences & behavior
Author, co-author :
Aubinet, Charlène  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Cassol, Helena ;  Université de Liège - ULiège > Département d'aérospatiale et mécanique > Ingénierie des véhicules terrestres
Gosseries, Olivia  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Bahri, Mohamed Ali  ;  Université de Liège - ULiège > CRC In vivo Imaging-Aging & Memory
Larroque, Stephen Karl  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Majerus, Steve  ;  Université de Liège - ULiège > Département de Psychologie > Département de Psychologie
Martial, Charlotte  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Martens, Géraldine  ;  Université de Liège - ULiège > GIGA
Carrière, Manon ;  Université de Liège - ULiège > GIGA
Chatelle, Camille ;  Coma Science Group, GIGA-Consciousness, University of Liège, Liege, Belgium, Centre du Cerveau², University Hospital of Liège, Liege, Belgium
Laureys, Steven  ;  Université de Liège - ULiège > GIGA Consciousness-Coma Science Group
Thibaut, Aurore ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Language :
English
Title :
Brain Metabolism but Not Gray Matter Volume Underlies the Presence of Language Function in the Minimally Conscious State (MCS): MCS+ Versus MCS− Neuroimaging Differences
Publication date :
2020
Journal title :
Neurorehabilitation and Neural Repair
ISSN :
1545-9683
eISSN :
1552-6844
Publisher :
SAGE
Volume :
34
Issue :
2
Pages :
172-184
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
JSMF - James S McDonnell Foundation [US-MO] [US-MO]
FERB - Fondazione Europea Ricerca Biomedica [IT]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
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