Harnessing LRIG1-mediated Inhibition of Receptor Tyrosine Kinases for Cancer Therapy

[en] Leucine-rich repeats and immunoglobulin-like domains containing protein 1 (LRIG1) is an endogenous feedback regulator of receptor tyrosine kinases (RTKs) and was recently shown to inhibit growth of different types of malignancies. Additionally, this multifaceted RTK inhibitor was reported to be a tumor suppressor, a stem cell regulator, and a modulator of different cellular phenotypes. This mini-review provides a concise and up-to-date summary about the known functions of LRIG1 and its related family members, with a special emphasis on underlying molecular mechanisms and the opportunities for harnessing its therapeutic potential against cancer.

Research center :

Luxembourg Institute of Health

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Neirinckx, Virginie ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques

Hedman, Hakan; Umea University > Department of Radiation Sciences

Niclou, Simone P; Luxembourg Institute of Health > Department of Oncology

Language :

English

Title :

Harnessing LRIG1-mediated Inhibition of Receptor Tyrosine Kinases for Cancer Therapy

Publication date :

August 2017

Journal title :

Biochimica et Biophysica Acta - Reviews on Cancer

ISSN :

0304-419X

Publisher :

Elsevier, Netherlands

Volume :

1868

Issue :

Pages :

109-116

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 26 June 2020

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Bibliography

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