Article (Scientific journals)
Cortical progenitor biology: key features mediating proliferation versus differentiation.
Uzquiano, Ana; Gladwyn-Ng, Ivan; Nguyen, Laurent et al.
2018In Journal of Neurochemistry
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Keywords :
Cortical neurogenesis; asymmetric); cell division (symmetric; cerebral cortex evolution; mouse mutant; neurodevelopment; progenitor cell
Abstract :
[en] The cerebral cortex is a highly organized structure whose development depends on diverse progenitor cell types, namely apical radial glia, intermediate progenitors and basal radial glia cells, which are responsible for the production of the correct neuronal output. In recent years, these progenitor cell types have been deeply studied, particularly basal radial glial and their role in cortical expansion and gyrification. We review here a broad series of factors to regulate progenitor behavior and daughter cell fate. We first describe the different neuronal progenitor types, emphasizing the differences between lissencephalic and gyrencephalic species. We then review key factors shown to influence progenitor proliferation versus differentiation, discussing their roles in progenitor dynamics, neuronal production and potentially brain size and complexity. Although spindle orientation has been considered a critical factor for mode of division and daughter cell output, we discuss other features that are emerging as crucial for these processes such as organelle and cell cycle dynamics. Additionally, we highlight the importance of adhesion molecules and the polarity complex for correct cortical development. Finally, we briefly discuss studies assessing progenitor multipotency and its possible contribution to the production of a specific neuronal populations. This review hence summarizes recent aspects of cortical progenitor cell biology, and pinpoints emerging features critical for their behavior. This article is protected by copyright. All rights reserved.
Disciplines :
Neurology
Author, co-author :
Uzquiano, Ana
Gladwyn-Ng, Ivan ;  Université de Liège - ULiège > Giga - Neurosciences
Nguyen, Laurent  ;  Université de Liège - ULiège > GIGA - Neurosciences
Reiner, Orly
Gotz, Magdalena
Matsuzaki, Fumio
Francis, Fiona
Language :
English
Title :
Cortical progenitor biology: key features mediating proliferation versus differentiation.
Publication date :
2018
Journal title :
Journal of Neurochemistry
ISSN :
0022-3042
eISSN :
1471-4159
Publisher :
Blackwell, Oxford, United Kingdom
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 25 June 2020

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