Article (Scientific journals)
COVID-19 in an international European liver transplant recipient cohort.
Becchetti, Chiara; Zambelli, Marco Fabrizio; Pasulo, Luisa et al.
2020In Gut, 69 (10), p. 1832-1840
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Keywords :
chronic liver disease; infectious disease; orthotopic liver transplantation; organ transplantation; liver; complication
Abstract :
[en] OBJECTIVE: Knowledge on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in liver transplant recipients is lacking, particularly in terms of severity of the disease. The aim of this study was to describe the demographic, baseline clinical characteristics and early outcomes of a European cohort of liver transplant recipients with SARS-CoV-2 infection. DESIGN: We conducted an international prospective study across Europe on liver transplant recipients with SARS-CoV-2 infection confirmed by microbiological assay during the first outbreak of COVID-19 pandemic. Baseline characteristics, clinical presentation, management of immunosuppressive therapy and outcomes were collected. RESULTS: 57 patients were included (70% male, median (IQR) age at diagnosis 65 (57-70) years). 21 (37%), 32 (56%) and 21 (37%) patients had one cardiovascular disease, arterial hypertension and diabetes mellitus, respectively. The most common symptoms were fever (79%), cough (55%), dyspnoea (46%), fatigue or myalgia (56%) and GI symptoms (33%). Immunosuppression was reduced in 22 recipients (37%) and discontinued in 4 (7%). With this regard, no impact on outcome was observed. Forty-one (72%) subjects were hospitalised and 11 (19%) developed acute respiratory distress syndrome. Overall, we estimated a case fatality rate of 12% (95% CI 5% to 24%), which increased to 17% (95% CI 7% to 32%) among hospitalised patients. Five out of the seven patients who died had a history of cancer. CONCLUSION: In this European multicentre prospective study of liver transplant recipients, COVID-19 was associated with an overall and in-hospital fatality rate of 12% (95% CI 5% to 24%) and 17% (95% CI 7% to 32%), respectively. A history of cancer was more frequent in patients with poorer outcome.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Becchetti, Chiara
Zambelli, Marco Fabrizio
Pasulo, Luisa
Donato, Maria Francesca
Invernizzi, Federica
Detry, Olivier  ;  Université de Liège - ULiège > Département des sciences cliniques > Pathologie chirurgicale abdominale et endocrinienne
Dahlqvist, Géraldine
Ciccarelli, Olga
Morelli, Maria Cristina
Fraga, Montserrat
Svegliati-Baroni, Gianluca
van Vlierberghe, Hans
Coenraad, Minneke J.
Romero, Mario Cristobal
de Gottardi, Andrea
Toniutto, Pierluigi
Del Prete, Luca
Abbati, Claudia
Samuel, Didier
Pirenne, Jacques
Nevens, Frederik
Dufour, Jean-François
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Title :
COVID-19 in an international European liver transplant recipient cohort.
Publication date :
October 2020
Journal title :
Publisher :
BMJ Publishing Group, United Kingdom
Volume :
Issue :
Pages :
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
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since 24 June 2020


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