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Poster (Scientific congresses and symposiums)
Role of ephrin-A5 in the survival and connectivity of spiral ganglion neurons
Defourny, Jean; Hadjab, Saida; Lallemend, François et al.
20077th BSN meeting
 

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Abstract :
[en] In mammals, degeneration of peripheral auditory neurons constitutes one of the prime causes of the sensorineural hearing loss. We believe that studying the developing auditory portion of the inner ear can provide important insights to mechanisms that would regulate regeneration after injury. In that context, our work has focused on a family of proteins, ephrins and Eph receptors, since they have been shown to have a dynamic influence in regulating developmental functions including axonal growth and guidance, synaptic formation and functions and neurogenesis. We have shown that ephrin-A5, EphA4 and EphA7 are expressed in the cell bodies of the spiral ganglion neurons, at different stages of the cochlear development. Ephrin-A5 also seems to be present in the hair cells of the organ of Corti. On the one hand, we demonstrated that activation of the signaling pathway by complexed ephrin-A5 in spiral ganglion explants reduced neuronal survival. On the other hand, an increase of neuronal survival was observed when blocking this mechanism of transduction by monomeric ephrin-A5. Taken together, these results suggest a role for ephrin/Eph signaling in regulating neuronal population generated in the spiral ganglion, especially during the post-natal period of the cochlear innervation.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Defourny, Jean  ;  Université de Liège - ULiège > Neurosciences-Cellular and tissular biology
Hadjab, Saida
Lallemend, François
Borgs, Laurence
Vandenbosch, Renaud  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques
Beukelaers, Pierre
Bodson, Morgan
Breuskin, Ingrid
POIRRIER, Anne-Lise  ;  Centre Hospitalier Universitaire de Liège - CHU > Autres Services Médicaux > Service d'ORL, d'audiophonologie et de chir. cervico-faciale
LEFEBVRE, Philippe ;  Centre Hospitalier Universitaire de Liège - CHU > Autres Services Médicaux > Service d'ORL, d'audiophonologie et de chir. cervico-faciale
Malgrange, Brigitte  ;  Université de Liège - ULiège > Stem Cells-Developmental Neurobiology
Language :
English
Title :
Role of ephrin-A5 in the survival and connectivity of spiral ganglion neurons
Publication date :
2007
Event name :
7th BSN meeting
Event organizer :
Belgian Society for Neuroscience
Event date :
2007
Available on ORBi :
since 14 June 2020

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