Article (Scientific journals)
Systematic Screening of Neonatal Sickle Cell Disease with HemoTypeSCTM Kit-Test: Case Study and Literature Review
TEBANDITE KASAI, Emmanuel; BOEMER, François; Marini Djang'Eing'A, Roland et al.
2020In Open Journal of Blood Diseases
Peer reviewed
 

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Keywords :
Sickle Cell Disease; Hemoglobin Phenotype; HemoTypeSCTM; Neonates
Abstract :
[en] HemoTypeSCTM test is a new cheap, faster, and appropriate screening method for neonatal diagnosis of sickle cell disease. The literature reports a few cases of its applicability. This study extends the cases study and reviews the available literature. The sample consisted of 99 subjects, including 87 newborns (36 girls and 51 boys; 1.9 - 4.9 kg BW) sampled among 566 babies bone at six hospitals in Kisangani city (Democratic Republic of Congo) during March-April 2019; height infant-adolescents (<18 years); and four adults. Duplicate blood samples of 75 newborns, spotted on filter paper, were transferred to Liège in Belgium for LC-MS test confirmation. Of 99 subjects, 74.74% tested HbAA, 24.26% HbAS and 1% HbSS. The prevalence of HbAS compared to the HbAA phenotype was 15/60 (20%) by HemoTypeSCTM and 14/61 (18.7%) by LC-MS. The concordance between the two methods was 98.3% or a discordance of 1.7%. The findings support the validity of the HemoTypeSCTM test as a sensitive, specific point of care test, cheap and reliable for poor African populations.
Research center :
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège
Disciplines :
Pediatrics
Author, co-author :
TEBANDITE KASAI, Emmanuel;  Université de Kisangani > Département de Pédiatrie
BOEMER, François  ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire Biochimie Génétique
Marini Djang'Eing'A, Roland ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
KADIMA NTOKAMUNDA, Justin;  University of Rwanda
BATINA AGASA, Salomon;  Université de Kisangani > Département de Médecine Interne
NGBONDA DAULY, Nestor;  Université de Kisangani > Département de Pédiatrie
ALWORONG'A OPARA, Jean-Pierre;  Université de Kisangani > Département de Pédiatrie
Language :
English
Title :
Systematic Screening of Neonatal Sickle Cell Disease with HemoTypeSCTM Kit-Test: Case Study and Literature Review
Publication date :
02 March 2020
Journal title :
Open Journal of Blood Diseases
eISSN :
2164-3199
Peer reviewed :
Peer reviewed
Name of the research project :
DREPAKIS
Funders :
Académie de Recherche et d'Enseignement Supérieur (Belgique). Coopération au Développement - ARES. CCD
Available on ORBi :
since 12 June 2020

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