Alphatic polyesters; Reactive extrusion; Ring opening polymerization
Abstract :
[en] Due to their biodegradability and biocompatibility, aliphatic polyesters received a considerable attention for a
wide range of applications, in particular in medical and pharmaceutical fields. Aliphatic polyesters are usually
synthesized by ring opening polymerization in a batch mode. In this work, a reactive extrusion polymerization
was optimized to synthesise in a continuous way poly-L-lactide, poly-D,L-lactide, and poly-D,L-lactide-co-glycolide
50:50. A lab scale co-rotating twin screw extruder adapted for pharmaceutical products and medical devices was
used after optimizing the geometry of screws and barrel. Polymerization was conducted in the presence of tin(II)
2-ethylhexanoate as catalyst and a monohydroxylated polyethylene glycol as initiator. The optimized procedure
allowed producing high molecular weight polyesters (Mn in the range [15−100 kDa]) in a controlled way on a
time scale of some minutes, with a capacity of at least 100 g/h and with monomer residues lower than 5%.
Comparison of macromolecular features and thermal properties of the resulting polyesters of different Mn with
those prepared in a batch process allowed concluding to the similarity of these materials. Reactive extrusion
polymerization represents therefore a very attractive methodology to produce in a continuous, rapid and robust
way aliphatic polyesters suitable for a wide range of pharmaceutical, medical or nowadays applications.
Research center :
CEIB - Centre Interfacultaire des Biomatériaux - ULiège
Disciplines :
Materials science & engineering
Author, co-author :
Regibeau, Nicolas ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Tilkin, Rémi ; Université de Liège - ULiège > Department of Chemical Engineering > Nanomaterials, Catalysis, Electrochemistry
Lombart, François
Heinrichs, Benoît ; Université de Liège - ULiège > Department of Chemical Engineering > Génie chimique - Nanomatériaux et interfaces
Grandfils, Christian ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Language :
English
Title :
Synthesis of medical grade PLLA, PDLLA, and PLGA by a reactive extrusion polymerization
Publication date :
07 May 2020
Journal title :
Materials Today Communications
eISSN :
2352-4928
Publisher :
Elsevier, Oxford, United Kingdom
Volume :
24
Pages :
101208
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
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