Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection

[en] The interferons (IFNs) are a primary defense against pathogens because of the strong antiviral activities they induce. IFNs can be classified into three groups: type I, type II and type III, according to their genetic, structural, and functional characteristics and their receptors on the cell surface. The type I IFNs are the largest group and include IFN-α, IFN-β, IFN-ε, IFN-ω, IFN-κ, IFN-δ, IFN-τ and IFN-ζ. The use of IFNs for the treatment of viral infectious diseases on their antiviral activity may become an important therapeutic option, for example, IFN-α is well known for the successful treatment of hepatitis B and C virus infections, and interest is increasing in the antiviral efficacy of other novel IFN classes and their potential applications. Therefore, in this review, we summarize the recent progress in the study of the biological activities of all the type I IFN classes and their potential applications in the treatment of infections with immunodeficiency virus, hepatitis viruses, and influenza viruses.

Disciplines :

Microbiology

Author, co-author :

Li, Shifang ; Université de Liège - ULiège > FARAH

Gong, Meijiao ; Université de Liège - ULiège > FARAH

Zhao, FuRong

Shao, JunJun

Xie, Yinli

Zhang, Yongguang

Chang, Huiyun

Language :

English

Title :

Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection

Publication date :

December 2018

Journal title :

Cellular Physiology and Biochemistry

ISSN :

1015-8987

eISSN :

1421-9778

Publisher :

Karger, Basel, Switzerland

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 10 June 2020

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61 (6 by ULiège)

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85 (3 by ULiège)

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Scopus citations^®

125

Scopus citations^®
without self-citations

124

OpenCitations

OpenAlex citations

150

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